Rovedder 2014.

Methods	Design: single‐centre, parallel RCT; 3‐months home‐based exercise programme. Inclusion criteria: participants diagnosed with CF in accordance with the criteria of the consensus;aged ≥16 years; ≥ 30 days of clinical respiratory disease stability. Exclusion criteria: participants who refused to take part in the study; pregnant ladies; individuals with heart disease, orthopaedic or traumatological problems.
Participants	41 participants with CF. Group demographics Exercise group (n = 22): mean (SD) age 23.8 (8.3) years. Control group (n = 19): mean (SD) age 25.4 (6.9) years. 2 study participants in the exercise group could not be assessed at the 3‐months follow up due to lung transplant assessment.
Interventions	3‐month home‐based exercise programme. Group 1: participants received printed guidance for aerobic and muscle strengthening exercises and were advised to perform the programme on a daily basis. Weekly telephone contacts were performed during the 3‐month period. Group 2: control group participants received standard programme without any specific exercise instructions.
Outcomes	Included in this study were: HRQoL; FEV1; FVC; walking distance (6MWT); SaO2 at peak exercise; RR at peak exercise; peak exercise HR; dyspnoea and fatigue scores; upper and lower body muscle strength.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Participants were randomly allocated in blocks of 6 to the exercise or control group. A computer programme was used to generate randomisation sequence.
Allocation concealment (selection bias)	Unclear risk	Not discussed.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not possible to blind participants to intervention. 1 researcher was blinded to the randomisation and intervention and was responsible for database entries.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcome assessors were blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	2 participants in the exercise group could not be assessed at the 3‐month visit due to submission to the lung transplant programme. Intention‐to‐treat analysis was used and imputations for missing data were performed for these 2 participants.
Selective reporting (reporting bias)	Low risk	All outcome detailed in methods were reported in results. Data reported for all time points.
Other bias	Unclear risk	Clearly stated inclusion and exclusion criteria and described method of statistical analysis used. Baseline between‐group differences existed in BMI which could possibly impact on HRQoL (primary outcome).