Selvadurai 2002.
| Methods | Design: single‐centre, parallel RCT; hospital admission for recurrent chest infections. Inclusion criteria: children with CF, aged 8 ‐ 16 years who were admitted the the Royal Alexandria Hospital for Children for the treatment of an infectious pulmonary exacerbation. Exclusion criteria: children with known pulmonary hypertension, or who required daytime oxygen prior to the pulmonary exacerbation which led to the hospital admission. |
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| Participants | 66 children with CF (28 males, 38 females). No dropouts.
Group demographics Aerobic training group (n = 22): mean (SD) age 13.2 (2.0) years), 9 males and 13 females. Resistance training group (n = 22): mean (SD) age 13.1 (2.1) years, 10 males and 12 females. Control group (n = 22): mean (SD) age 13.2 (2.0) years, 9 male and 1 females. |
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| Interventions | Short‐term aerobic and anaerobic/strength training study during hospital admission (mean duration 18.7 days, range 14 ‐ 36 days).
Group 1: 30 min supervised aerobic exercise training 5 times per week. Group 2: 30 min supervised resistance training 5 times per week. Group 3: no specific training. |
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| Outcomes | Included in this study were: VO2 peak; peak VE; VCO₂; peak HR; HRQoL; FEV1; FVC; weight; lower limb strength; and fat‐free mass. | |
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Random allocation in sets of 6. No details given for generation of sequence. |
| Allocation concealment (selection bias) | Low risk | Concealed information inside opaque envelopes. |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not possible to blind participants to intervention. Unclear whether personnel blinded. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear whether outcome assessors blinded. |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Stated no dropouts. |
| Selective reporting (reporting bias) | Unclear risk | Did not report on all secondary outcomes detailed in methods (e.g. VE, VCO2, RQ) in results. Data reported for all time points. |
| Other bias | Low risk | Clearly stated inclusion and exclusion criteria. Described statistical methods used to analyse data. |