| Study | Reason for exclusion |
|---|---|
| Alarie 2012 | This study compared the acute cardiovascular response in participants playing different active video games. No control group included. |
| Albinni 2004 | This study was designed with the exercise group as the control group, therefore we could not compare data with baseline, no physical exercise training as per our protocol. |
| Amelina 2006 | IMT training and not physical exercise training as per our protocol. |
| Andreasson 1987 | Not a randomised controlled study. |
| Aquino 2006 | This study was designed with the aim of comparing the effectiveness of a single treatment sessions of exercise and PEP on sputum clearance. Participants in this study did not undertake a programme of physical training. |
| Asher 1982 | IMT training and not physical exercise training as per our protocol. |
| Balestri 2004 | This study was designed with the aim of comparing the effectiveness of a single treatment session of exercise and PEP on sputum clearance. Participants in this study did not undertake a programme of physical training. |
| Balfour 1998 | Not a physical exercise training study, comparison of different tests for assessing exercise capacity. |
| Barry 2001 | Not a randomised controlled study. |
| Bieli 2017 | Study of respiratory muscle endurance training, not a physical exercise training study. |
| Bilton 1992 | This study was designed with the aim of comparing the effectiveness of a single treatment session of exercise or physiotherapy or exercise and physiotherapy on sputum clearance and lung function. Participants in this study did not undertake a programme of physical training. |
| Bongers 2015 | Study evaluating the clinical usefulness of the steep ramp test and not a physical training study. |
| Calik‐Kutukcu 2016 | No control group with no physical training. |
| Chang 2015 | Study of methods for evaluating muscle function and not a physical training study. |
| Chatham 1997 | This study involved respiratory muscle training exclusively. This intervention does not constitute physical training as defined within our protocol. |
| de Jong 1994 | Not a randomised controlled study. |
| del Corral Nunez‐Flores 2011 | No control group with no physical training. |
| Dwyer 2008 | Study duration insufficient, |
| Dwyer 2017 | Study duration insufficient, |
| Edlund 1986 | Not a randomised controlled study. |
| Falk 1988 | This study was designed with the aim of comparing the effectiveness of a single treatment session of exercise or positive expiratory pressure on lung function. Participants in this study did not undertake a programme of physical training. |
| Giacomodonato 2015 | Study of respiratory muscle endurance training and not a physical training study. |
| Gruet 2012 | No control group with no physical training. |
| Haynes 2016 | Evaluation of the incremental step test not a study of physical training. |
| Heijerman 1992 | Not a randomised controlled study. |
| Irons 2012 | Not a physical exercise training study, examines effect of a singing program compared to no singing. |
| Kriemler 2016 | Study duration insufficient, only 3 single day interventions on non‐consecutive days of a week. |
| Kuys 2011 | Compares Nintendo Wii exercise training to an existing exercise programme, no control group with no physical training. |
| Lannefors 1992 | This study was designed with the aim of comparing the effectiveness of a single treatment session of exercise and FET or positive expiratory pressure and FET or postural drainage, thoracic expansion exercises and FET on mucous clearance. Participants in this study did not undertake programme of physical training. |
| Lima 2014 | No physical exercise training study, study looks at effect of non‐invasive ventilation on exercise capacity and lung function. |
| Lowman 2012 | No control group with no physical training. |
| NCT02277860 | Not a randomised controlled study, single arm trial of physical exercise, |
| NCT02715921 | Not a randomised controlled study, single arm trial of physical exercise, |
| NCT02821130 | A study of CFTR potentiator therapy and effects on exercise capacity. |
| NCT02875366 | A study of CFTR potentiator therapy and effects on exercise capacity. |
| NCT03117764 | Not a randomised controlled study, study of the effect of antibiotics on muscular strength and not physical training. |
| Orenstein 1981 | Not a randomised controlled study. |
| Orenstein 2004 | Compares aerobic training to upper‐body strength training, no control group with no physical training. |
| Ozaydin 2010 | IMT training and not physical exercise training as per our protocol. |
| Patterson 2004 | Study to evaluate the efficacy of the test of incremental respiratory endurance, not a physical training study. |
| Petrovic 2013 | Not a randomised controlled study. |
| Rand 2012 | Not a physical exercise training study. This study was designed to develop an incremental field exercise test for children with CF. |
| Reix 2012 | Acute study comparing exercise with expiratory breathing manoeuvres to breathing techniques for airway clearance. |
| Salh 1989 | Not a randomised controlled study. |
| Salonini 2015 | A comparison of two exercise interventions (Xbox Kinect versus stationary cycle). No control group with no physical training. |
| Shaw 2016 | No control group with no physical training. |
| Stanghelle 1998 | Not a randomised controlled study. |
| Tuzin 1998 | Not a randomised controlled study. |
| Vallier 2016 | Study to evaluate modified shuttle test and not a study of physical training. |
| Vivodtzev 2013 | This study evaluated neuromuscular electrical stimulation prior to endurance training in people with CF. No control group with no physical training. |
| Wheatley 2015 | Intervention only given on 3 single days, comparison of physical training and albuterol for airway clearance. |
CF: cystic fibrosis FET: forced expiration technique IMT: inspiratory muscle training PEP: positive expiratory pressure