NCT02552043.

Methods	Design: parallel RCT; duration 6 weeks; open‐label; single‐centre study at Universidad Autonoma de Madrid, Spain.
Participants	Enrolment goal: 41 participants with CF. Inclusion criteria: males and females aged 7‐18 years diagnosed with CF; clinically stable with no exacerbations of the disease in the previous 6 weeks to the inclusion date. Exclusion criteria: clinical evidence of cardiovascular, neuromuscular or osteo‐articular co‐morbidities that limit the participation in exercise programmes; lung transplant candidates and participants that followed any kind of rehabilitation programme 12 months before the study.
Interventions	Intervention group: 30 ‐ 60 min exercise using a Nintendo Wii platform with the game EA SPORTS ACTIVE 2, 5 days/week for 6 weeks. The exercise activities are loaded into each participant's console during the clinical interview and the exercises adjusted according to their age: <12 years and >13 years. The program consists of 6 different workouts (1st and 2nd weeks: legs exercises; 3rd week: upper limb exercises; 4th week: thorax exercises; 5th and 6th weeks: cardio exercises) with gradually increasing intensities reaching the maximum load at the end of the training. Control group: routine clinical management.
Outcomes	Included in this study were: exercise capacity (6MWT; modified shuttle walk test); muscular strength (horizontal jump test, medicine ball throw, handgrip strength); HRQoL using 3 versions of the CFQ‐R (CFQ‐R 6‐11, CFQ‐R 14+, CFQ‐R Parents).
Notes	The aim of this study is to evaluate the efficacy of a long‐term domiciliary exercise program using the Wii video game platform as a training modality in people with CF.