Gupta 2017.

Trial name or title	Effects of exercise intervention program on bone mineral accretion in children and adolescents with cystic fibrosis.
Methods	RCT (stratified block randomization, allocation concealed using sequentially numbered, sealed, opaque envelopes, open label). Design: parallel. Single centre. Duration: 1 year.
Participants	Total sample size: 30. Inclusion criteria: children with confirmed diagnosis of CF (sweat chloride ≥ 60 mEq/l on 2 or more occasions in a child with clinical features suggestive of CF), stable medical condition (not required IV antibiotics for last 1 month prior to enrolment), FEV1 ≥ 20%. Exclusion criteria: children unwilling to participate in the study; presence of any prior diagnosed musculoskeletal disorder such as rheumatoid arthritis, muscular dystrophy, chronic renal failure. Age minimum: 6 years. Age maximum: 18 years. Gender: both.
Interventions	Intervention group: exercise program ‐ resistance exercise and plyometric jumping exercise, 1x daily, 3x a week for 1 year. Control group: no exercise program, continue with regular physical activity for 1 year.
Outcomes	Primary outcome Mean bone mineral density at 1 year. Secondary outcomes Lung function (FEV1 and FVC) at baseline, 3 months, 6 months, 9 months and at the end of 1 year. Exercise capacity at baseline and at the end of 1 year. CFQ‐R at baseline and at the end of year.
Starting date	Date of first enrolment: 08 September 2012.
Contact information	Sumita Gupta (Physiotherapist) All India Institute of Medical Sciences, Department of Pediatrics, AIIMS, Ansari Nagar,New Delhi, DELHI 110029, India. Email sumitabisoi@gmail.com Professor SK Kabra Department of Pediatrics, AIIMS, Ansari Nagar,New Delhi, DELHI 110029, India. Email: skkabra@hotmail.com
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