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. 2017 Nov 6;2017(11):CD011373. doi: 10.1002/14651858.CD011373.pub2

Comparison 6. Direct oral anticoagulants versus warfarin: fixed‐effect model.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All strokes and systemic embolic events 5 12545 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.65, 1.01]
2 Major bleeding 5 12521 Risk Ratio (M‐H, Fixed, 95% CI) 0.79 [0.67, 0.92]