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. 2017 Nov 9;2017(11):CD011770. doi: 10.1002/14651858.CD011770.pub2

Comparison 23. Postoperative pain intensity at 48 hours: perineural versus intravenous dexamethasone.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Postoperative pain intensity at 48 hours 3 227 Mean Difference (IV, Random, 95% CI) 0.13 [‐0.35, 0.61]
2 Postoperative pain intensity at 48 hours: additive versus no additive subgroups 3 227 Mean Difference (IV, Random, 95% CI) 0.13 [‐0.35, 0.61]
2.1 Additive 1 50 Mean Difference (IV, Random, 95% CI) 0.80 [‐0.51, 2.11]
2.2 No additive 2 177 Mean Difference (IV, Random, 95% CI) 0.02 [‐0.50, 0.54]
3 Postoperative pain intensity at 48 hours: low‐ versus high‐dose dexamethasone subgroups 3 227 Mean Difference (IV, Random, 95% CI) 0.13 [‐0.35, 0.61]
3.1 Low‐dose dexamethasone 1 99 Mean Difference (IV, Random, 95% CI) 0.0 [‐0.59, 0.59]
3.2 High‐dose dexamethasone 2 128 Mean Difference (IV, Random, 95% CI) 0.39 [‐0.45, 1.24]
4 Postoperative pain intensity at 48 hours: high/unclear versus low risk of bias subgroups 3 227 Mean Difference (IV, Random, 95% CI) 0.13 [‐0.35, 0.61]
4.1 High/unclear risk of bias 1 99 Mean Difference (IV, Random, 95% CI) 0.0 [‐0.59, 0.59]
4.2 Low risk of bias 2 128 Mean Difference (IV, Random, 95% CI) 0.39 [‐0.45, 1.24]