Test subgroups		Number of studies	Number of affected pregnancies	Number of unaffected pregnanciesa
Reference standard
Autosomes, unselected population
MPSS	mixed reference standardb	1	11	1730
TMPS	karyotypingc	1	11	181
	mixed reference standard	3	107	20,468
Autosomes, selected high‐risk population
MPSS	karyotyping	22	1075	7028
	mixed reference standard	10	433	8769
TMPS	karyotyping	7	378	4282
SCA, selected high‐risk population
MPSS	karyotyping	10	134	3943
	mixed reference standard	2	17	3509
TMPS	karyotyping	4	96	968
Ethnicity
Autosomes, unselected population
MPSS	more than 50% Asiand	1	11	1730
TMPS	more than 50% Caucasiane	3	107	20,468
	not reported	1	11	181
Autosomes, selected high‐risk population
MPSS	more than 50% Asian	14	206	6589
	more than 50% Caucasian	7	843	6262
	not reported	11	459	2946
TMPS	more than 50% Caucasian	3	237	3744
	not reported	4	141	538
SCA, selected high‐risk population
MPSS	more than 50% Asian	5	25	1852
	more than 50% Caucasian	5	96	4286
	not reported	2	30	1314
TMPS	more than 50% Caucasian	1	56	116
	not reported	3	40	852