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. 2017 Nov 3;2017(11):CD005661. doi: 10.1002/14651858.CD005661.pub2

Cameron 1987.

Methods RCT
Methods to control for contributory patient factors: none described
Participants Age:
Group 1 (mean): 60.2 years
Group 2 (mean): 61.6 years
Gender:
Group 1: 56.0% female
Group 2: 54.5% female
Type of incision:
Group 1: midline 66.7%; paramedian 33.3%
Group 2: midline 56.0%; paramedian 44.0%
Type of surgery:
Group 1: emergent 19.6%; biliary 29.8%, gastric 17.7%, colon 29.1%, other 23.4%
Group 2: emergent 19.9%; biliary 32.9%, gastric 23.1%, colon 21.0%, other 23.1%
Contamination classification of included participants:
Group 1: clean 77.3%, clean‐contaminated 9.2%, contaminated 13.5%
Group 2: clean 79.7%, clean‐contaminated 6.3%, contaminated 14.0%
Pre‐operative antibiotic use: "antibiotic prophylaxis was given according to the surgeon's usual routine"
Prognostic patient factors:
Group 1: obesity 26%, corticosteroid use 1.4%, jaundice 3.5%
Group 2: obesity 24%, corticosteroid use 2.1%, jaundice 3.5%
Inclusion criteria: patients undergoing laparotomy by vertical abdominal incision
Exclusion criteria: patients who were being re‐operated on via the original incision were excluded
Interventions Comparisons reported:
Group 1
 Suture: polypropylene (monofilament, non‐absorbable)
 Suturing technique: interrupted, "figure‐of‐eight"
 Closure method: mass
 Group 2:
 Suture: PDS (monofilament, slowly absorbable)
 Suturing technique: interrupted, "figure‐of‐eight"
 Closure method: mass
Surgeon characteristics:
 Group 1: senior resident 56.0%, junior resident 40.4%
Group 2: senior resident 52.4%, junior resident 46.8%
Outcomes Incisional hernia: no definition provided
Follow‐up duration: minimum 12 months (mean 14.7 months)
Wound infection: "discharge of pus, up to one month of follow‐up"
 Wound dehiscence: "burst abdomen"
 Suture sinus or fistula: no definition provided
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No information provided
Allocation concealment (selection bias) Low risk "At the end of the operation, the circulating nurse drew a sealed envelope and informed the surgeon of the suture to be used."
Blinding (performance bias and detection bias) 
 All outcomes Low risk "This assessment was 'double‐blind', as neither the examiner nor the participant knew which suture had been used."
Incomplete outcome data (attrition bias) 
 All outcomes High risk High loss to follow‐up (51/141 in group 1, 43/143 in group 2)
Selective reporting (reporting bias) Low risk Hernia (at least 1 year); dehiscence and wound infection outcomes all reported
Other bias Low risk The study appears to be free of other sources of bias