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. 2017 Nov 3;2017(11):CD005661. doi: 10.1002/14651858.CD005661.pub2

Hsiao 2000.

Methods RCT
Methods to control for contributory patient factors: none
Participants Age:
Group 1 (mean): 60.9 years
Group 2 (mean): 58.5 years
Gender:
Group 1: 44% female
Group 2: 48% female
Type of incision:
 Group 1: midline 50.5%, paramedian 4.3%, subcostal 26.1%, subcostal plus midline 4.9%, bilateral subcostal plus midline 14.1%
Group 2: midline 45.5%, paramedian 5.1%, subcostal 26.3%, subcostal plus midline 5.1%, bilateral subcostal plus midline 17.9%
Type of surgery: all surgeries were elective
Group 1: upper GI 17.4%, hepato‐pancreaticobiliary 63.6%, lower GI 15.2%, vascular 3.3%, other 0.5%
Group 2: upper GI 15.4%, hepato‐pancreaticobiliary 65.4%, lower GI 13.5%, vascular 1.2%, other 4.5%
Contamination classification of included participants: not described
Pre‐operative antibiotic use: all participants received cefmetazole and metronidazole
Prognostic patient factors:
Group 1: mean BMI 23.0, malignancy 58.1%
Group 2: mean BMI 22.8, malignancy 54.4%
Inclusion criteria: patients undergoing elective laparotomy
Exclusion criteria: emergency laparotomies, history of laparotomy within 3 months, previous incisional hernia
Interventions Comparisons reported:
Group 1
 Suture: polyglactin‐910 (multifilament, fast absorbable)
 Suturing technique: continuous
 Closure method: mass
 Group 2:
 Suture: PDS (monofilament, slowly absorbable)
 Suturing technique: continuous
 Closure method: mass
Surgeon characteristics: same surgeon for all procedures
Outcomes Incisional hernia: visible and palpable defect in the fascia or a protrusion in the wound when the participant was carefully examined in both horizontal and vertical positions
Follow‐up duration: 24 months
Wound infection: purulent discharge from the wound, confirmed by standard signs including fever and an elevated leukocyte count
Dehiscence: no definition provided
Sinus or fistula: no definition provided
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Randomised based on last digit of hospital patient number
Allocation concealment (selection bias) High risk Randomised based on last digit of hospital patient number
Blinding (performance bias and detection bias) 
 All outcomes Low risk Outcome assessor blinded
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All participants accounted for and analysed
Selective reporting (reporting bias) Low risk Hernia (at least 1 year); dehiscence and wound infection outcomes all reported
Other bias Low risk The study appears to be free of other sources of bias