2. Subgrouping data for primary outcomes.
| Analysis described | Total mortality: Number of studies, participants, events |
Total mortality: Relative Risk (95% CI), Heterogeneity ‐ I2, % |
CVD mortality: Number of studies, participants, events |
CVD mortality: Relative Risk (95% CI), Heterogeneity ‐ I2, % |
CVD events: Number of studies, participants, events |
CVD events: Relative Risk (95% CI), Heterogeneity ‐ I2, % |
| Main meta‐analysis | 21, 71790, 4292 | 0.98 (0.93 to 1.04), 0 | 16, 65978, 1407 | 0.94 (0.85 to 1.04), 0 | 23, 65508, 4887 | 0.86 (0.77 to 0.96), 50 |
| Sub‐group 'mean follow‐up ≤2 years' | 9, 12272, 767 | 1.05 (0.91 to 1.20), 0 | 6, 11434, 523 | 1.04 (0.88 to 1.23), 0 | 12, 13844, 689 | 0.95 (0.84 to 1.09), 0 |
| Sub‐group 'mean follow‐up >2 years' | 12, 59518, 3525 | 0.97 (0.91 to 1.03), 0 | 10, 54544, 884 | 0.89 (0.78 to 1.01), 0 | 11, 51664, 4198 | 0.78 (0.67 to 0.92), 72 |
| Sub‐group 'low CVD risk' | 10, 66776, 3717 | 0.99 (0.93 to 1.05), 0 | 6, 59682, 879 | 0.93 (0.77 to 1.13), 35 | 10, 58338, 3408 | 0.93 (0.82 to 1.05), 13 |
| Sub‐group 'moderate CVD risk' | 3, 1200, 47 | 0.69 (0.39 to 1.21), 0 | 2, 663, 23 | 0.66 (0.28 to 1.53), 0 | 5, 1537, 143 | 0.57 (0.33 to 0.99), 53 |
| Sub‐group 'high CVD risk' | 8, 3814, 528 | 0.95 (0.78 to 1.17), 24 | 8, 5633, 505 | 0.95 (0.80 to 1.12), 0 | 8, 5633, 1336 | 0.88 (0.75 to 1.02), 58 |
| Sub‐group 'Dietary advice' | 13, 60320, 3201 | 0.98 (0.92 to 1.05), 0 | 9, 54703, 796 | 0.97 (0.85 to 1.12), 0 | 12, 52595, 3998 | 0.85 (0.72 to 1.00), 62 |
| Sub‐group 'dietary advice plus supplementation' | 4, 1372, 219 | 0.80 (0.63 to 1.02), 0 | 4, 1372, 169 | 0.87 (0.62 to 1.21), 15 | 4, 1372, 395 | 0.78 (0.66 to 0.92), 0 |
| Sub‐group 'diet provided' | 4, 10098, 872 | 1.03 (0.92 to 1.15), 0 | 3, 9903, 442 | 0.93 (0.69 to 1.26), 63 | 7, 11541, 494 | 0.91 (0.73 to 1.14), 19 |
| Sub‐group 'total fat in control <30%E' | 4, 3592, 81 | 0.93 (0.61 to 1.43), 0 | 2, 618, 25 | 0.76 (0.35 to 1.64), 0 | 3, 1155, 152 | 0.82 (0.65 to 1.03), 1 |
| Sub‐group 'total fat in control 30‐34.9%E' | 4, 3450, 333 | 0.91 (0.46 to 1.81), 23 | 3, 3344, 21 | 0.72 (0.15 to 3.53), 51 | 5, 1429, 74 | 0.93 (0.62 to 1.39), 0 |
| Sub‐group 'total fat in control 35‐39.9%E' | 8, 62820, 3311 | 1.00 (0.94 to 1.07), 0 | 6, 60088, 1054 | 1.00 (0.88 to 1.12), 0 | 10, 60919, 4034 | 0.96 (0.84 to 1.10), 44 |
| Sub‐group 'total fat in control 40+%E' | 3, 1491, 454 | 0.96 (0.83 to 1.11), 0 | 3, 1491, 227 | 0.80 (0.63 to 1.02), 0 | 3, 1491, 435 | 0.83 (0.71 to 0.97), 0 |
| Sub‐group 'saturated fat in control <10%E' | 2, 3625, 316 | 0.97 (0.79 to 1.20), 0 | 1, 3088, 7 | 0.40 (0.08 to 2.08), ‐ | 1, 537, 2 | 0.20 (0.01 to 4.13), ‐ |
| Sub‐group 'saturated fat in control 10‐14.9%E' | 5, 50089, 2520 | 1.01 (0.77 to 1.32), 32 | 5, 49631, 558 | 0.98 (0.83 to 1.16), 0 | 11, 51610, 3565 | 0.97 (0.87 to 1.07), 10 |
| Sub‐group 'saturated fat in control 15‐19.9%E' | 6, 14598, 1134 | 1.02 (0.92 to 1.13), 0 | 4, 11966, 657 | 0.90 (0.74 to 1.11), 37 | 5, 11991, 793 | 0.86 (0.68 to 1.09), 64 |
| Sub‐group 'saturated fat in control 20+%E' | 0, 0, 0 | ‐ | 0, 0, 0 | ‐ | 0, 0, 0 | ‐ |
| Sub‐group 'studies of men' | 11, 9604, 1224 | 0.97 (0.87 to 1.08), 7 | 9, 8951, 735 | 0.89 (0.77 to 1.02), 0 | 13, 10589, 1162 | 0.82 (0.74 to 0.90), 0 |
| Sub‐group 'studies of women' | 5, 59130, 2960 | 0.99 (0.92 to 1.07), 0 | 4, 56587, 658 | 1.03 (0.88 to 1.20), 0 | 4, 53605, 3566 | 1.04 (0.89 to 1.21), 53 |
| Sub‐group 'studies of men and women' | 5, 3056, 108 | 0.84 (0.58 to 1.22), 0 | 3, 440, 14 | 0.45 (0.15 to 1.37), 0 | 6, 1314, 159 | 0.60 (0.32 to 1.13), 66 |
| Sub‐group 'community setting' | 17, 61692, 3420 | 0.97 (0.91 to 1.03), 0 | 13, 56077, 965 | 0.95 (0.84 to 1.07), 0 | 20, 55605, 4405 | 0.84 (0.73 to 0.95), 51 |
| Sub‐group 'residential setting' | 4, 10098, 872 | 1.03 (0.92 to 1.15), 0 | 3, 9903, 442 | 0.93 (0.69 to 1.26), 63 | 3, 9903, 482 | 0.94 (0.71 to 1.24), 63 |
| Sub‐group 'published in 1960s' | 6, 2178, 580 | 0.92 (0.80 to 1.06), 2 | 5, 1983, 326 | 0.80, 0.64 to 1.00), 11 | 9, 3621, 638 | 0.81 (0.71 to 0.92), 0 |
| Sub‐group 'published in 1970s' | 3, 9515, 584 | 1.13 (0.95 to 1.33), 9 | 2, 9057, 304 | 1.06 (0.85 to 1.33), 0 | 3, 9159, 301 | 0.71 (0.35 to 1.43), 88 |
| Sub‐group 'published in 1980s' | 1, 2033, 224 | 0.98 (0.76 to 1.25), ‐ | 1, 2033, 201 | 1.01 (0.77 to 1.31), ‐ | 1, 2033, 283 | 0.92 (0.74 to 1.15), ‐ |
| Sub‐group 'published in 1990s' | 5, 4880, 137 | 0.90 (0.65 to 1.26), 0 | 3, 364, 11 | 0.27 (0.07 to 1.08), 0 | 3, 364, 57 | 0.51 (0.32 to 0.81), 0 |
| Sub‐group 'published since 2000' | 6, 53184, 2767 | 0.98 (0.91 to 1.05), 0 | 5, 52541, 565 | 0.98 (0.83 to 1.15), 0 | 7, 50331, 3608 | 0.96 (0.85 to 1.08), 29 |