Rose 1965.

Methods	RCT
Participants	Men (?) with angina or following MI (UK) CVD risk: high Control: randomised 26, analysed 18 Intervention ‐ olive: randomised 28, analysed 12 Intervention ‐ corn: randomised 26, analysed 13 Mean years in trial: control 1.7, olive 1.5, corn 1.5 % male: unclear (100%?) Age: mean control 58.8, olive 55.0, corn 52.6 (all <70)
Interventions	Modified fat vs. usual diet Control aims: usual diet Intervention aims ‐olive: restrict dietary fat, plus 80g/day olive oil provided Intervention aims ‐ corn: restrict dietary fat, plus 80g/day corn oil provided Control methods: usual physician care plus follow up clinic monthly, then every 2 months, no dietary fat advice or oil provided Intervention methods: usual physician care plus follow up clinic monthly, then every 2 months, dietary fat advice plus oil provided Total fat intake (at 18 months): corn 50.5 (sd unclear), olive 46.2 (sd unclear), cont 32.6 (sd unclear)%E Saturated fat intake: unclear Style: diet advice & supplement (oil) Setting: community
Outcomes	Stated trial outcomes: cardiac events Data available on total mortality? yes Cardiovascular mortality? yes Events available for combined cardiovascular events: cardiovascular deaths, non‐fatal MI, angina, stroke Secondary outcomes: stroke (none), non‐fatal and total MI Tertiary outcomes: total cholesterol
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"sealed envelopes"
Allocation concealment (selection bias)	Unclear risk	Unclear if envelopes were opaque
Blinding (performance bias and detection bias) All outcomes	High risk	Physician blinding: inadequate Participant blinding: inadequate
Incomplete outcome data (attrition bias) All outcomes	High risk	Some lost to follow up by 2 years
Selective reporting (reporting bias)	Low risk	Not relevant for primary and secondary outcomes as all trialists asked for data
Other bias	Low risk
Free of systematic difference in care?	Low risk	All received conventional treatments at the discretion of the physicians, all attended a special follow up clinic. See Control and Intervention Methods in Interventions section of the Table of Characteristics of Included Studies
Free of dietary differences other than fat?	Low risk	See Control and Intervention Aims in Interventions section of the Table of Characteristics of Included Studies