Hudecek 2012.
Methods | Parallel group single centre RCT. Number of women randomised: 212. Number of women analysed: not clear, assumed it was 212. Number of withdrawals: not reported. Power calculation for sample size not reported. Source of funding: not reported. |
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Participants | Participants recruited from Gynecological and Obstetric Clinic of Medical Facility of Masaryk University and the University Hospital Brno, Czech Republic. Inclusion criteria: reproductive aged females with uterine symptomatic myomatosis. Exclusion criteria: not reported. |
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Interventions | Rx: Goserelin acetate 3.6 mg SC 3 times once every 4 weeks, N = 120. Control: No pretreatment before surgery, N = 92. 42.5% of participants had laparoscopic myomectomy and 57.5% of participants had open laparotomic myomectomy. |
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Outcomes | Perioperative blood loss. Duration of surgery. Length of hospital stay. Perioperative and postoperative complications. |
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Notes | Translated from Czech by Petr Tomek, Auckland University. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method of randomisation not reported. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not reported. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not reported but stated as ITT. |
Selective reporting (reporting bias) | Low risk | All prespecified outcomes reported. SLL outcomes not reported as these were not measured in this review. |
Other bias | Unclear risk | Czech and English abstracts of the article report different numbers of women treated with open myomectomy (78 vs. 44 respectively). |