Summary of findings 3. LOD 4‐5 compared to 2 or fewer punctures for symptom relief in women with polycystic ovary syndrome.
| LOD 4 ‐ 5 punctures compared to 2 or fewer punctures for symptom relief in women with polycystic ovary syndrome | ||||||
| Patient or population: Women with symptoms of PCOS Setting: Clinic or hospital Intervention: LOD 4 ‐ 5 punctures Comparison: 2 or fewer punctures | ||||||
| Outcomes | Relative effect (95% CI) | Anticipated absolute effects* (95% CI) | Quality of the evidence (GRADE) | What happens | ||
| Without LOD 4‐5 | With LOD 4‐5 | Difference | ||||
| Menstrual regularity at 6 months ‐ LOD 4 ‐ 5 coagulation points compared to 2 or fewer N of participants: 73 (2 RCTs) | OR 16.04 (4.19 to 61.34) | 13.9% | 72.1% (40.3 to 90.8) | 58.2% more (26.4 more to 76.9 more) | ⊕⊕⊝⊝ LOW 1, 2 | |
| Menstrual regularity at 6 months ‐ LOD (4 ‐ 5 laser coagulation points) vs 1 laser coagulation point per ovary N of participants: 40 (1 RCT) | OR 19.00 (2.12 to 170.38) | 5.0% | 50.0% (10.0 to 90.0) | 45.0% more (5 more to 85 more) | ⊕⊕⊝⊝ LOW 1, 2 | |
| Menstrual regularity at 6 months ‐ LOD 4 punctures vs 2 punctures per ovary N of participants: 33 (1 RCT) | OR 14.00 (2.60 to 75.41) | 25.0% | 82.4% (46.4 to 96.2) | 57.4% more (21.4 more to 71.2 more) | ⊕⊕⊝⊝ LOW 1, 2 | |
| Improvement in androgenic symptoms | No data available | |||||
| Harms LOD 4 ‐ 5 versus fewer punctures |
No data available | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1Downgraded one level for serious risk of bias: Included studies not double‐blinded or methods of randomization unclear. 2Downgraded one level for serious imprecision.