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. 2017 Nov 10;2017(11):CD009526. doi: 10.1002/14651858.CD009526.pub2

Comparison 1. LOD vs medical interventions.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Menstrual regularity 2   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.1 LOD vs Metformin alone 2   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2 Menstrual regularity 5   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 LOD vs Metformin + Clomiphene 2 332 Odds Ratio (M‐H, Fixed, 95% CI) 1.02 [0.64, 1.64]
2.2 LOD vs Gonadotropins 1 35 Odds Ratio (M‐H, Fixed, 95% CI) 19.2 [3.17, 116.45]
2.3 LOD vs Letrozole 1 260 Odds Ratio (M‐H, Fixed, 95% CI) 1.08 [0.64, 1.84]
2.4 LOD vs Metformin + Letrozole 1 146 Odds Ratio (M‐H, Fixed, 95% CI) 0.95 [0.49, 1.81]
3 Improvement in androgenic symptoms (hirsutism/acne) 2   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1 LOD vs Metformin 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 LOD vs Gonadotrophins 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Harms 3   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 LOD vs Metformin + Clomiphen 2 332 Odds Ratio (M‐H, Fixed, 95% CI) 0.05 [0.01, 0.36]
4.2 LOD vs Gonadotrophins 1 33 Odds Ratio (M‐H, Fixed, 95% CI) 0.08 [0.00, 1.61]
5 BMI 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.1 LOD vs Metformin 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 LOD vs Metformin + Letrozole 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Testosterone and free androgen index 5   Mean Difference (IV, Fixed, 95% CI) Totals not selected
6.1 LOD vs Metformin 2   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.2 LOD vs GnRHa + OCP 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.3 LOD vs Metformin + Letrozole 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6.4 LOD versus Rosiglitazone 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Fasting Glucose:Insulin 3   Mean Difference (IV, Fixed, 95% CI) Totals not selected
7.1 LOD vs Rosiglitazone 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 LOD vs Metformin 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.3 LOD vs Metformin + Letrozole 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]