| Methods |
A randomised controlled trial |
| Participants |
120 women with polycystic ovary syndrome and clomiphene citrate resistance between January 2007 and December 2009 in the Women's Health Centre and Physiology Department, Assiut University, Egypt. |
| Interventions |
Patients were assigned randomly to 2 groups of 60 women each. Group A received an adjusted thermal dose based on ovarian volume with use of a new model for dose calculation (60 J/cm3 of ovarian tissue), and group B received 600 J per ovary through 4 ovarian holes regardless of size (traditional form of LOD). 1 month afterward, the hormonal profile was re‐evaluated, and second‐look laparoscopy was performed in women who had not conceived by 6 months to evaluate adnexal adhesions |
| Outcomes |
Menstrual cycle regularity, hormonal profile including testosterone, BMI and adhesions |
| Notes |
Funding source: Not stated
Declarations of interest: None. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"Randomisation was done using a computer generated random table" |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Not stated but not possible due to study design |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
Not stated |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
5 lost to follow‐up |
| Selective reporting (reporting bias) |
Low risk |
None detected |
| Other bias |
Low risk |
None detected |
