Comparison 2. Hypoglycemia.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Percent of participating experiencing hypoglycemia	20		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Total episodes	16	6131	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.80, 1.08]
1.2 Severe episodes	17	5827	Odds Ratio (M‐H, Fixed, 95% CI)	0.73 [0.61, 0.87]
1.3 Nocturnal episodes	13	5406	Odds Ratio (M‐H, Fixed, 95% CI)	0.70 [0.63, 0.79]
2 Hypoglycemic events per 100 patient's days	19		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Total episodes	15	4704	Mean Difference (IV, Fixed, 95% CI)	‐0.77 [‐0.89, ‐0.65]
2.2 Severe episodes	15	4564	Mean Difference (IV, Fixed, 95% CI)	‐0.00 [‐0.02, 0.02]
2.3 Nocturnal episodes	17	4971	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.45, ‐0.34]