Comparison 3. Adverse Events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Number of serious adverse events	14	4878	Odds Ratio (M‐H, Fixed, 95% CI)	0.89 [0.66, 1.21]
2 Type of serious adverse events and reasons for death			Other data	No numeric data
3 Death	23	6787	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.03, 3.23]