Study	Reason for exclusion
Albright 2004	No RCT.
Alemzadeh 2003	Flexible multiple daily insulin versus conventional treatment, no RCT.
Alemzadeh 2005	Inetrvention, no RCT.
Heise 2003	RCT. Pharmakodynamic and pharmakokinetic profiles.
Hershon 2004	Subgroup analysis of Ratner et al.
Herwig 2007	No RCT. Extensio of one arm from Schober 2001.
Kiess 2004	Comment to Home et al.
Lepore 2000	RCT. Pharmakodynamic and pharmakokinetic profiles.
Lepore 2003	Most probably not an RCT with insulin pump as control.
Manini 2007	No RCT.
Mimouni 1979	No RCT.
Moretti 2005	Not RCT
Palmer 2004	Economic analysis based on meta‐analysis.
Ratner 2003	Review.
Saisho 2005	No RCT.
Urakami 2007	Not RCT
Wutte 2007	RCT, assessing dose response relationship of determir and NPH over 24 hours, without regarding efficacy or adverse outcomes.