| 7.1 Tranquilisation or asleep: 1. sedation |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 7.1.1 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
12.00 [1.66, 86.59] |
| 7.2 Behaviour: 1. mean endpoint score (Overt Aggression Scale (OAS), high = worse) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.2.1 + haloperidol vs haloperidol + promethazine ‐ short term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.30 [‐5.25, ‐1.35] |
| 7.2.2 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
1.70 [‐0.06, 3.46] |
| 7.3 Behaviour: 2. mean endpoint score (Overt Agitation Severity Scale (OASS) agitation scale, high = worse) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.3.1 + haloperidol vs haloperidol + promethazine ‐ short term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐16.00 [‐18.98, ‐13.02] |
| 7.3.2 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.70 [‐3.73, ‐1.67] |
| 7.4 Global state: 1. no improvement (number of participants with < 10 points on the OAS and OASS after 12 hours) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 7.4.1 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
25.00 [1.55, 403.99] |
| 7.5 Global state: 2. need for additional medication (mean dose, high = worse) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.5.1 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
0.63 [0.15, 1.11] |
| 7.6 Global state: 3. mean change score (Ramsey Sedation Scale, high = worse) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.6.1 + haloperidol vs haloperidol + promethazine ‐ short term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
0.60 [0.07, 1.13] |
| 7.6.2 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
0.00 [‐0.46, 0.46] |
| 7.7 Adverse effects/events: 1. extrapyramidal symptoms |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 7.7.1 + haloperidol vs haloperidol + promethazine ‐ medium term |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.60 [0.16, 2.29] |
| 7.8 Adverse effects/events: 2. specific |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 7.8.1 + haloperidol vs haloperidol + promethazine ‐ hypotension ‐ medium term |
1 |
60 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.67 [0.44, 6.36] |
