4. Risk of bias in included randomised controlled trials.

Study	Adequate sequence generation?	Adequate allocation concealment?	Blinding?	Incomplete outcome data addressed?	Free of selective reporting?	Free of other bias?
Einaudi 2008	Yes, according to additional information provided by trial authors, the rule for allocating interventions to children was based on some chance (random) process.	Yes, according to additional information provided by trial authors, the randomisation method did not allow investigator and child to know or influence allocation of treatment before eligible children entered the study.	Based on additional information provided by trial authors, care providers, children, and outcome assessors were not blinded.	Yes, no outcome data were missing.	No, "adrenal function completely recovered in the 12 children evaluated with subsequent low‐dose ACTH test (in 4, 3, and 5 patients after 4, 8, and 10 weeks, respectively)". However, it was not reported which of these children received prednisone and which received dexamethasone. Therefore, not all of the study's prespecified primary outcomes were reported.	Yes
Kuperman 2012	Yes, the rule for allocating interventions to children was based on some chance (random) process.	Yes, according to additional information provided by trial authors, the randomisation method did not allow investigator and child to know or influence allocation of treatment before eligible children entered the study.	Yes, based on additional information provided by trial authors, care providers, children, and outcome assessors were all blinded.	Outcomes were assessed for 83% to 93% of the study population.	Yes	Yes

ACTH: adrenocorticotropic hormone.