6. Prevalence and duration of adrenal insufficiency evaluated by a low‐dose ACTH stimulation test.
| Mahachoklertwattana et al | Therapy: prednisolone (cumulative dose 1120 mg/m2)a | ||||
| Time after cessation | 2 weeks | 4 weeks | 8 weeks | 12 weeks | 20 weeks |
| n insufficient/n totalb | 11/24 | 9/24 | 7/24 | 3/24 | 3/24 |
| Rix et al (1) | Therapy: prednisolone (cumulative dose 2257.5 mg/m2) | ||||
| Time after cessation | Before | 1 day | 3 days | 5 days | ‐ |
| n insufficient/n totalb | 0/13 | 16/17 | 8/15 | 8/17 | ‐ |
| Rix et al (2) | Therapy: prednisolone (cumulative dose 420 mg/m2)c | ||||
| Time after cessation | Before | 2 days | ‐ | ‐ | ‐ |
| n insufficient/n totalb | 2/13 | 13/13 | ‐ | ‐ | ‐ |
| Rix et al (3) | Therapy: dexamethasone (cumulative dose 236.25 mg/m2)c | ||||
| Time after cessation | Before | 1 day | 3 days | 7 days | ‐ |
| n insufficient/n totalb | 0/5 | 2/2 | 3/5 | 1/5 | ‐ |
| Einaudi et al (1) | Therapy: prednisone (cumulative dose 1477.5 mg/m2)d | ||||
| Time after cessation | 1 day | 7 to 14 days | 28 days | 42 days | 10 weeks |
| n insufficient/n totalb | 32/40 | 8/32 | 5/8 | 5/5 | 0/5 |
| Einaudi et al (2) | Therapy: dexamethasone (cumulative dose 246.25 mg/m2)d | ||||
| Time after cessation | 1 day | 7 to 14 days | 28 days | 42 days | 10 weeks |
| n insufficient/n totalb | 20/24 | 4/20 | 3/4 | 3/3 | 0/3 |
| Kuperman et al 2012 (1) | Therapy: prednisone (cumulative dose 1120 mg/m²) | ||||
| Time after cessation | Before (4 weeks after start of glucocorticoid treatment) | 1 week | 2 weeks | 3 weeks | 4 weeks |
| n insufficient/n totalb | 5/14 | 3/13 | 4/14 | 5/14 | 4/15 |
| Kuperman et al 2012 (2) | Therapy: dexamethasone (cumulative dose 168 mg/m²) | ||||
| Time after cessation | Before (4 weeks after start of glucocorticoid treatment) | 1 week | 2 weeks | 3 weeks | 4 weeks |
| n insufficient/n totalb | 1/12 | 3/13 | 5/11 | 3/10 | 3/12 |
| Perdomo‐Ramírez et al 2015 | Therapy: prednisone (cumulative dose 1837.5 mg/m2) | ||||
| Time after cessation | Before | 3 days | 1 week | 2 weeks | 4 weeks |
| n insufficient/n totalb | 0/40 | 29/40 | 11/28 | 3/11 | 0/3 |
|
Salem et al 2015 (1) (both induction and reinduction phases) |
Therapy: dexamethasone (cumulative dose unknown) | ||||
| Time after cessation | Before (at diagnosis) | 1 day to 18 weeks | 20 weeks | ||
| n insufficient/n totalb | 5/20 | No data on patient level were available. | All children recovered.e | ||
|
Salem et al 2015 (2) (both induction and reinduction phases) |
Therapy: prednisone (cumulative dose unknown) | ||||
| Time after cessation | Before (at diagnosis) | 1 day to 18 weeks | 20 weeks | ||
| n insufficient/n totalb | 6/20 | No data on patient level were available. | All children recovered.e | ||
ACTH, adrenocortiotropic hormone. a Four weeks after completion of induction therapy, children received maintenance therapy consisting of a 7‐day course of high‐dose dexamethasone 8 mg/m2/d every 4 weeks. Cumulative dose depended on how long the child had been followed up.
b If not all children were tested at all time points, then "n total" = n tested.
c All children first received prednisolone (cumulative dose 2257.5 mg/m2).
d After 7 days of prednisone (60 mg/m2/d, cumulative dose 420 mg/m2).
eFrom 4 weeks after cessation of glucocorticoid therapy, only children who were adrenal insufficient at that time point underwent further low‐dose ACTH testing every 2 weeks until adrenal recovery. Therefore it is unknown how many children were tested at 20 weeks (in both induction and reinduction phases).