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Unless otherwise stated, search terms are free text terms; MeSH = Medical subject heading (Medline medical index term); exp = exploded MeSH; the dollar sign ($) stands for any character(s); the question mark (?) substitutes one or no character; tw = text word; pt = publication type; sh = MeSH; adj = adjacent. MEDLINE I. Latent autoimmune diabetes (LADA): 1. LADA.tw. 2. SPIDDM.tw. 3. exp Diabetes Mellitus/ 4. diabet$.tw. 5. or/1‐4 6. slowly progressiv$.tw. 7. islet antibod$.tw. 8. islet cell antibod$.tw. 9. (autoantibod$ or auto‐antibod$).tw. 10. exp Autoantibodies/ 11. glutamic acid$ decarboxylas$.tw. 12. IA‐2.tw. 13. exp "Islets of Langerhans"/ 14. GAD.tw. 15. exp Glutamate Decarboxylase/ 16. or/6‐15 17. 5 and 16 II. RCT/CCT (senitive search) Part 1: 18. randomized controlled trial.pt. 19. controlled clinical trial.pt. 20. randomized controlled trials.sh. 21. random allocation.sh. 22. double‐blind method.sh. 23. single‐blind method.sh. 24. or/18‐23 Part 2: 25. clinical trial.pt. 26. exp clinical trials/ 27. (clinic$ adj25 trial$).ab,ti,ot. 28. ((singl$ or doubl$ or trebl$ or tripl$) adj (mask$ or blind$)).ab,ti,ot. 29. placebos.sh. 30. placebo$.ab,ti,ot. 31. random$.ab,ti,ot. 32. research design.sh. 33. (latin adj square).ab,ti,ot. 34. or/25‐33 Part 3: 35. comparative study.pt. 36. exp evaluation studies/ 37. follow‐up studies.sh. 38. prospective studies.sh. 39. (control$ or prospectiv$ or volunteer$).ab,ti,ot. 40. cross‐over studies.sh. 41. or/35‐40 42. 24 or 34 or 41 III. Meta‐analysis: 43. exp meta‐analysis/ 44. exp Review Literature/ 45. meta‐analysis.pt. 46. (meta‐analy$ or meta?analy$).ab,ti,ot. 47. ((review$ or search$) and (medical databas$ or medline or pubmed or embase or cochrane or systematic$)).ab,ti,ot. 48. or/43‐47 49. letter.pt. 50. comment.pt. 51. editorial.pt. 52. historical‐article.pt. 53. or/49‐52 54. ((systematic$ or quantitativ$ or methodologic$) adj (review$ or overview$)).ab,ti,ot. 55. (integrativ$ research review$ or research integration$).ab,ti,ot. 56. quantitativ$ synthes$.ab,ti,ot. 57. (pooling$ or pooled analys$ or mantel$ haenszel$).ab,ti,ot. 58. (peto$ or der?simonian$ or fixed effect$ or random effect$).ab,ti,ot. 59. or/54‐58 60. 48 not 53 61. 59 or 60 IV. LADA + RCT/CCT: 62. 17 and 42 V. LADA + Meta‐analysis: 63. 17 and 61 VI. IV. + V. 64. 62 or 63 65. limit 64 to yr="2007 ‐ 2010" 66. limit 65 to "all adult (19 plus years)" Web of Knowledge Topic=(Diabetes Mellitus OR diabet* OR LADA OR SPIDDM) AND Topic=(slowly progressiv* OR islet antibod* OR islet cell antibod* OR autoantibod* OR auto‐antibod* OR Autoantibodies OR glutamic acid* decarboxylas* OR IA‐2 OR "Islets of Langerhans" OR GAD OR Glutamate Decarboxylase) AND Topic=(ADULT) Timespan=2007‐2010. Databases=SCI‐EXPANDED, SSCI, CPCI‐S, CPCI‐SSH. ASSIA (CSA) 1. KW=LADA 2. KW=SPIDDM 3. DE="diabetes mellitus" [Assia Thesaurus term] 4. KW=diabet* 5. (1 OR 2 OR 3 OR 4) 6. KW=slowly progressiv* 7. KW=islet antibod* 8. KW=islet cell antibod* 9. KW=(autoantibod* or auto‐antibod*) 10.KW=(glutamic acid* decarboxylas*) 11.KW= IA‐2 12 KW=GAD 13. KW=Islets of Langerhans 14. (6 OR7 0R 8 OR9 OR 10 OR11 OR 12 OR 13 15. (5 AND 14) 16. LIMIT 15 to 2007‐2010 CINAHL 1. LADA 2. SPIDDM 3. MH "Diabetes Mellitus+"   [Cinahl Subject Heading – exploded] 4. diabet* 5. or/1‐4 6. slowly progressive* 7. islet antibody* 8. islet cell antibody* 9. (autoantibody* or auto‐antibod*) 10. MH "Autoantibodies"   11. glutamic acid* decarboxylas* 12. IA‐2 13. MH "Islets of Langerhans" 14. GAD.tw. 15. Glutamate Decarboxylase  [Not a Cinahl Subject Heading] 16. or/6‐15 17. (5 and 16) 18. Limit 17 to Publication Year 2007‐2010 19. Limit 18 to Age Groups  Adult 19+ The Cochrane Library 1. LADA 2. SPIDDM 3. MH "Diabetes Mellitus+"   [MESH term – exploded] 4. diabet* 5. or/1‐4 6. slowly progressive* 7. islet antibody* 8. islet cell antibody* 9. (autoantibody* or auto‐antibod*) 10. MH "Autoantibodies+"   [MESH term ‐ exploded] 11. glutamic acid* decarboxylas* 12. IA‐2 13. MH "Islets of Langerhans+" [MESH term – exploded] 14. GAD 15. MH "Glutamate Decarboxylase" [MESH term] 16. or/6‐15 17. (5 and 16) 18. Limit 17 to Publication Year 2007‐2010 EMBASE 1         LADA.tw.                                                             2         SPIDDM.tw.                                                       3         diabet$.tw.                                                         4        exp Diabetes Mellitus/                         5         or/1‐4                                                               6.        slowly progressiv$.tw.                   7         islet antibod$.tw.                                             8         islet cell antibod$.tw.                                     9         (autoantibod$ or auto‐antibod$).tw.      10       exp Autoantibodies/                                      11       glutamic acid$ decarboxylas$.tw.              12       IA‐2.tw.                                                                13       GAD.tw.                                                               14       exp Glutamate Decarboxylase/ 15       exp pancreas islet/                                      16      islet of langerhans.mp.                                         17      or/6‐16                                                           18       5 and 17                                                      19      exp adult/                                                  20       human/ 21      18 and 19 and 20                                        22       LIMIT 2007‐2010  NOTE – keywords were all searched in the TITLE, ABSTRACT, and KEYWORDS fields.