4. Adverse effects.
| Adverse effect | Number of participants affected | Studies |
| Deep vein thrombosis | 1 participants withdrawn from physiotherapy group. | Verplancke 2005 |
| Contracture at subtalar joint | 1 participants withdrawn from the casting + placebo group. | Verplancke 2005 |
| No adverse events or changes in alertness level were observed in the baclofen group or placebo arm | Not applicable. | Meythaler 1996 |
| Unspecified "treatment emergent AE [adverse effects]": "none were unexpected" | 7/23 participants, no other information given. | Gracies 2015 (O'Dell 2015) |
| Skin rashes/oedema/tolerability issues | No pseudoelastic device required adjustment for comfort; 30% of traditional devices did. Families reported novel treatment tolerated for 40% longer than traditional (Pittaccio 2013). 2 participants adherence to splinting was affected by 'skin problems' and 'poor tolerance' (Leung 2014). 50% of participants in casting group and 41.7% of participants in casting + botulinum toxin A group developed 'minor skin damage'. Overall, 90% of those resolved spontaneously or with therapeutic dressing (Verplancke 2005). |
Leung 2014; Pittaccio 2013; Verplancke 2005 |
| Fainting, fatigue, storming1 | Several participants' adherence to the tilt table was affected due to fainting, fatigue and storming. | Leung 2014 |
1When someone with a head injury responds to a sensation with a tonic posture or sympathetic response.