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. 2017 Dec 14;2017(12):CD009789. doi: 10.1002/14651858.CD009789.pub2

Bell 2016.

Methods Double‐blind randomised controlled trial (parallel design)
Participants Setting: laboratory; England
n = 16 semi professional male soccer players (8 in the experimental group; 8 in the placebo group)
Mean age 25 (SD 4) years
Inclusion/exclusion criteria
Inclusion criteria required participants to have trained in soccer consistently across the preceding 3 years and be free of any lower limb injury for the preceding 6 months
Interventions Intervention
Participants were instructed to consume 30 mL of the supplement twice per day (0800 and 1800 hours) for 7 consecutive days (4 days pretrial and on each trial day). The supplement was a commercially available Montmorency cherry concentrate (CherryActive, Sunbury, UK); containing a total anthocyanin content of 73.5 mg·L−1 of cyanidin‐3‐glucoside, a total phenolic content of 178.8 gallic acid equivalent·L−1 and an antioxidant capacity (TEAC) of 0.58 trolox equivalents·L−1
Placebo
A commercially available, less than 5% fruit, cordial, mixed with water and maltodextrin (MyProtein Ltd, Northwich, UK) until matched for energy content of the intervention (102 kcal)
Duration
7 days
Outcomes PRIMARY
Muscle soreness was assessed using a 0 to 200 mm visual analogue scale where 0 is "no pain" and 200 is "unbearably painful". Participants rated their soreness after completing a squat to approximately a 90° knee flexion before standing and immediately marked upon the scale to indicate their level of soreness
SECONDARY
Maximum voluntary isometric contraction of the dominant knee extensors was determined using a strain gauge (MIE Medical Research Ltd., Leeds, UK). Participants were given standardised verbal encouragement for the duration of each of the 3 maximum 3‐second contractions. Each contraction was separated by 1 minute
Sprint performance (20 m ‐ infrared timing gates)
Agility: 5‐0‐5 agility test (infrared timing gates)
Power: counter movement jump (jump mat)
Exercise type 12 × 20 m run sprints, departing every 60 seconds followed by an adapted version of the Loughborough Intermittent Shuttle Test (LIST) (6 x 15‐minute sections)
Sources of funding The Cherry Marketing Institute (a not for profit organisation) provided financial support for the analysis of inflammatory indices
Notes Authors were contacted on 3 February 2017 to request raw data for delayed onset muscle soreness and maximal voluntary isometric contraction and responded on 3 February 2017
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk No details in manuscript
Authors confirmed via email on 3 February 2017 that stratified randomisation based on aerobic fitness and coin toss was employed
Allocation concealment (selection bias) Low risk Manuscript states: "All supplements were prepared by an independent member of the department prepared in opaque bottles in order to maintain the double blind design"
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Double‐blind
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Double‐blind
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No details in manuscript
Authors confirmed via email on 3 February 2017 that all participants completed the study
Selective reporting (reporting bias) High risk Delayed onset muscle soreness data immediately post‐exercise not recorded or reported
Adverse effects of antioxidant supplementation were not reported
Other bias Unclear risk Manuscript states that participants "were also provided with a diet record diary and a list of foods to avoid throughout the 4 days prior to and during the trial period"
No information on NSAIDs or medication