Bryer 2006.

Methods	Randomised controlled trial (parallel design)
Participants	Setting: laboratory, USA n = 18 young, untrained males who did not weight train for 6 months, mean age 24.4 (SEM 1.7) years Inclusion/exclusion criteria All participants were prescreened, in good health, abstained from vitamin or herbal supplements for at least 6 months and were free of any muscular injuries
Interventions	Intervention Vitamin C supplementation (3 g per day) Placebo Starch pills 3 capsules per day and participants were asked to keep food records Duration Supplementation given 2 weeks prior and 4 days after exercise
Outcomes	PRIMARY Delayed onset muscle soreness was assessed by means of a linear scale from 1 to 10 in a rested position and in response to palpation on the arms of the muscle where 1 is "no pain" and 10 is "extreme pain" SECONDARY Isometric force was conducted on an isokinetic dynamometer (Biodex System 3 Isokinetic Dynamometer, Biodex Medical Systems, Shirely, NY). Participants performed 3 concentric maximum voluntary contractions (MVC) and the forces were recorded for both the dominant and non‐dominant arms through a full range of motion at a speed of 1.75 rad/second. The highest force obtained with no movement of the lever arm was accepted as the maximum isometric force. Range of motion was assessed on both arms using a goniometer placed on markings from the medial aspect of th elbow of the humerus.
Exercise type	70 eccentric actions using the elbow flexors
Sources of funding	None
Notes	Authors were contacted via email on 25 November 2013 to request data for delayed onset muscle soreness, maximal voluntary isometric contraction and range of motion, but did not respond
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details in manuscript Authors were contacted via email on 25 November 2013 but no information was provided
Allocation concealment (selection bias)	Unclear risk	Participants were given numbered containers for the 3 capsules per day Authors were contacted via email on 25 November 2013 but no information was provided
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details provided in the manuscript Authors were contacted via email on 25 November 2013 but no information was provided
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details provided
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed the study with no adverse outcomes
Selective reporting (reporting bias)	High risk	No published protocol available All outcomes reported at all time points Adverse effects of antioxidant supplementation were not reported
Other bias	Low risk	Participants were asked to refrain from using any supplements; medication and diet was controlled in both groups