Laupheimer 2014.

Methods	Randomised controlled trial (parallel design)
Participants	Setting: field; UK n = 7 (experimental group of 3, placebo group of 4) well trained distance runners, age range 40 to 55 years Originally 8 (all males) were recruited but 1 participant in the experimental group was excluded because of a viral infection during the study Inclusion/exclusion criteria Inclusion criteria were male gender and age 20 to 55 years. The male gender and age were chosen to ensure a homogenous cohort and to optimise the safety of the use of resveratrol Exclusion criteria included a past medical history of chronic inflammatory medical conditions, muscle disorders or heart conditions, and a drug history of immune suppressants or anti‐inflammatories
Interventions	Intervention 600 mg of resveratrol daily for 7 days and immediately before the marathon 2 x 100 mg tablets were taken 3 times daily Placebo Not specified Duration 9 days
Outcomes	PRIMARY General soreness on both legs; delayed onset muscle soreness, 10‐point visual analogue scale: 0 "complete absence of pain" to 10 "indicating extreme soreness with noticeable pain and stiffness at all times"
Exercise type	Running the London marathon race in 2010
Sources of funding	None declared
Notes	Participants were asked not to alter their diet in any way and were not given any nutrition or hydration advice prior to the race Authors were contacted to request raw data for delayed onset muscle soreness on 18 February 2016 and responded on 18 February 2016
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer block randomisation
Allocation concealment (selection bias)	Low risk	Double‐blind Before randomisation 2 different sets of envelopes had been prepared by an independent person not associated with the study
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	All outcomes reported at all time points
Selective reporting (reporting bias)	Low risk	All outcomes reported at all time points "None of the seven participants reported any adverse effects during the study period or during the marathon itself"
Other bias	Low risk	Participants were asked not to alter their diet in any way and were not given any nutrition or hydration advice prior to the race Participants were instructed to avoid anti‐inflammatory medication