Trombold 2010.

Methods	Randomised controlled trial (cross‐over design) Separated by a 14‐day washout
Participants	Setting: laboratory; USA n = 16 healthy, non‐smoking, recreationally active males, mean age 24 (SD 1.4) years Inclusion/exclusion criteria Participants were disqualified if they had participated in resistance exercise training of any kind in the previous 3 months, were currently participating in a formalised endurance training programme or had previous history of upper body injury. Other exclusion criteria included a recent weight change of more than 5 kg, history of hypertension, use of anti‐inflammatory drugs, angiotensin converting enzyme inhibitors lipid‐lowering medications or selective serotonin reuptake inhibitors.
Interventions	Intervention Pomegranate juice POM Wonderful 500 mL twice daily, 650 mg polyphenols, consisting of 95.5% ellagitannins, 3.5% ellagic acid and 1% anthocyanins Placebo 35 g carbohydrate + colouring and flavouring to match the pomegranate juice Duration 2 doses per day separated by 12 hours; 2 x 9‐day treatment periods separated by a 14‐day washout
Outcomes	PRIMARY Delayed onset muscle soreness of the elbow flexor muscles was determined before each isometric strength test using a 0 to 10 visual analogue scale where 0 is "no soreness" and 10 is "unbearable soreness". The rating was obtained before the measurement of strength while performing unloaded elbow flexion of the tested arm. SECONDARY Maximal isometric strength in elbow extensors was performed on a modified preacher curl bench. Force was recorded using a load cell (LC101‐500; Omega Engineering, Stamford, CT) secured to the ground using a galvanised steel cable and a strap secured to the waist of the participant. The participant performed 4 trials, 2 at both 150 degrees and 135 degrees of complete elbow extension, with a 180‐second rest in between each trial. Strength was reported as the average of the peak values at angles 150 and 135 degrees of elbow flexion.
Exercise type	2 sets of 20 maximal eccentric elbow flexion exercises
Sources of funding	The study was supported by a grant from POM Wonderful, L.L.C.
Notes	2 doses of 480 mL of the drink consumed daily separated by 12 hours. Participants were reminded to take the products verbally and via email communication to consume the experimental supplements at the required times Authors were contacted to request raw data for delayed onset muscle soreness and maximal voluntary isometric contraction on 2 November 2013 and responded on 5 December 2013
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details in manuscript Authors were contacted on 26 May 2016 via email with no response
Allocation concealment (selection bias)	Unclear risk	No details in manuscript Authors were contacted on 26 May 2016 via email with no response
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed the study
Selective reporting (reporting bias)	High risk	No published protocol available All outcomes reported at all time points Adverse effects of antioxidant supplementation were not reported
Other bias	Low risk	Participants were asked to refrain from using anti‐inflammatory drugs or other supplements that could reduce soreness