Comparison 1. Ergonomic keyboard versus placebo keyboard.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Short‐term improvement in CTS symptoms (pain) (3 months or less)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 At 6 weeks (Protouch Keyboard)	1	20	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐1.51, 1.11]
1.2 At end of 12 weeks treatment (Protouch Keyboard)	1	20	Mean Difference (IV, Random, 95% CI)	‐2.4 [‐4.45, ‐0.35]
2 Short‐term improvement in CTS symptoms (Phalen test time (seconds)) (3 months or less)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Right hand at end of 12 weeks treatment (Protouch Keyboard)	1	18	Mean Difference (IV, Fixed, 95% CI)	14.20 [‐3.20, 31.60]
2.2 Left hand at end of 12 weeks treatment (Protouch Keyboard)	1	14	Mean Difference (IV, Fixed, 95% CI)	12.70 [‐9.88, 35.28]
3 Short‐term improvement in functional ability (3 months or less)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 At 6 weeks (Protouch Keyboard)	1	20	Mean Difference (IV, Random, 95% CI)	‐1.20 [‐10.01, 7.61]
3.2 At end of 12 weeks treatment (Protouch Keyboard)	1	20	Mean Difference (IV, Random, 95% CI)	‐2.20 [‐11.57, 7.17]
3.3 Change from 6 to 12 weeks (Protouch Keyboard)	1	20	Mean Difference (IV, Random, 95% CI)	1.0 [‐3.68, 5.68]
4 Short‐term improvement in palm‐wrist sensory latency (ms) (3 months or less)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 Right hand at end of 12 weeks treatment (Protouch Keyboard)	1	14	Mean Difference (IV, Random, 95% CI)	0.28 [‐0.09, 0.65]
4.2 Left hand at end of 12 weeks treatment (Protouch Keyboard)	1	12	Mean Difference (IV, Random, 95% CI)	‐0.14 [‐0.46, 0.18]
5 Long‐term improvement in CTS symptoms (pain change scores) (> 3 months)	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
5.1 Change from baseline to end of 6 months treatment (Apple Adjustable Keyboard)	1	22	Mean Difference (IV, Random, 95% CI)	0.7 [‐0.97, 2.37]
5.2 Change from baseline to end of 6 months treatment (Comfort Keyboard System)	1	22	Mean Difference (IV, Random, 95% CI)	0.97 [‐0.64, 2.58]
5.3 Change from baseline to end of 6 months treatment (Microsoft Natural Keyboard)	1	22	Mean Difference (IV, Random, 95% CI)	0.79 [‐1.53, 3.11]