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. 2017 Dec 15;2017(12):CD001188. doi: 10.1002/14651858.CD001188.pub5

Hollis 1993.

Methods Country: USA (Portland, OR)
 Recruitment: Internal medicine/family clinics
Participants 2691 internal medicine/family clinic adults who reported being a smoker on a questionnaire
Interventions 1. Brief physician advice (30 secs and pamphlet from nurse)
 2. Brief physician message plus nurse who promoted self‐quit attempts ‐ advice, CO feedback, 10‐min video and manual (1 of 3 types) + follow‐up call and materials
 3. Brief physician advice plus nurse‐promoted group programme ‐ advice, CO, + video‐ask to join group with schedule, coupon, etc, follow‐up calls
 4. Brief physician advice, and nurse‐offered choice between self‐directed and group‐assisted quit ‐ shown both types of materials
 Intensity: High
Outcomes Abstinence at 1 yr (2 point prevalence)
 Validation: Saliva cotinine at 12 m
Notes All 3 nurse‐mediated interventions compared with 1. Saliva samples only obtained for approx half of reported quitters. Compliance and confirmation rates did not differ between groups
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk "Two random digits contained in the patient's health record number were used to assign patients to one of ... four interventions."
Allocation concealment (selection bias) High risk See above
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Smoking status missing for 24% of participants at 12 m; "response rates did not differ significantly across treatment groups." Non‐respondents counted as smokers