8. Drug‐related adverse events reported in randomised trials comparing regimens aimed to normalise elevated bone turnover (intensive) versus regimens aimed to control bone pain referable to Paget's disease of bone (symptomatic).

Study ID	Comparison	Side effect	Intensive	Symptomatic	RR (95% CI)
Langston 2010*	Intensive (661) vs. symptomatic (663)	All adverse events Serious adverse events Musculoskeletal Sensory Gastrointestinal Cardiovascular Arrythmia Cancer Renal Other	3429 345 691 203 172 360 13 (1.9%) 55 98 1850	3471 359 734 196 157 327 7 (1%) 47 78 1932	‐ ‐ ‐ ‐ ‐ ‐ 1.86 (0.75 to 4.64) ‐ ‐ ‐
Tan 2017	Intensive (270) vs. symptomatic (232)	All adverse events Serious adverse events Musculoskeletal Osteonecrosis of the jaw Delayed union of fracture Ophthalmic Uveitis Gastrointestinal Cardiovascular Arrythmia Cerebrovascular Central nervous system Endocrine Ear, nose or throat Genitourinary Haematological Respiratory Skin Miscellaneous	226 87 123 1 2 34 1 54 67 14 4 28 28 28 41 10 48 41 33	196 66 104 0 1 41 0 46 49 8 3 28 21 26 39 9 43 33 32	0.99 (0.91 to 1.07) 1.13 (0.87 to 1.48) 1.02 (0.84 to 1.23) 2.58 (0.11 to 63.01) 1.72 (0.16 to 18.83) 0.71 (0.47 to 1.08) 2.58 (0.11 to 63.01) 1.01 (0.71 to 1.43) 1.18 (0.85 to 1.62) 1.50 (0.64 to 3.52) 1.14 (0.26 to 5.07) 0.86 (0.52 to 1.41) 1.15 (0.68 to 1.96) 0.93 (0.56 to 1.53) 0.90 (0.61 to 1.35) 0.96 (0.40 to 2.31) 0.95 (0.66 to 1.39) 1.07 (0.70 to 1.63) 0.89 (0.56 to 1.40)

* Data represent total numbers of reported side effects regardless of numbers of participants who experienced them. The authors reported numbers of participants only for arrhythmia.