Dandashli 2005

Methods	Study design: randomised controlled trial Setting/location: Aleppo, Syria Study period: June 2009 to December 2010 (19 months) Sample size calculation: not described
Participants	Type of Leishmania: L tropica Inclusion criteria: not described Exclusion criteria: not described N randomised: 79 Withdrawals: 14 N assessed: 65. 46 participants (264 lesions) in the fluconazole group and 19 participants (102 lesions) in the placebo group Age (years): not described Sex: not described Baseline data: not described
Interventions	Type of interventions: Group 1: fluconazole orally 200 mg/d for 6 weeks Group 2: placebo orally for 6 weeks Duration of follow‐up: not reported
Outcomes	Healing rates: percentage of lesions 'cured' (follow‐up not reported) Adverse effects Time points reported: not described
Notes	Study funding sources: none reported Possible conflicts of interest: none declared This is an abstract
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "randomly assigned to treatment" Comment: insufficient detail was reported about the method used to generate the allocation sequence
Allocation concealment (selection bias)	Unclear risk	Quote: "randomly assigned to treatment" Comment: no further information provided
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information about blinding was provided
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information about blinding was provided
Incomplete outcome data (attrition bias) All outcomes	High risk	Quote: "Side effects were mild and similar in both groups" Comment: no further information on adverse effects was provided. Withdrawals: 14/79 (17.7%) and no ITT analyses were performed
Selective reporting (reporting bias)	Unclear risk	No protocol available. Not possible to allocate to high or low risk.
Other bias	High risk	Sample size calculation and baseline comparability were not correctly reported