Gholami 2000

Methods	Study design: randomised controlled trial Setting/location: Iran Study period: 24 months Sample size calculation: yes
Participants	Type of Leishmania:L major Inclusion criteria: CL confirmed with direct smear, age 5‐50 years, maximum number of lesions 3, duration of disease < 100 days Exclusion criteria: previous treatment for leishmaniasis, use of immunosuppressives, history of chronic systemic disease, lesions on face, pregnancy or lactating, age < 5 years, duration of disease > 100 days N randomised: 197 Withdrawals: 26 N assessed: 171. 96 were treated with garlic 5% cream and 75 with vehicle Mean age: garlic, 18.5 years; vehicle, 23.7 years Sex (male/female): garlic, 51/45; placebo, 38/37 Baseline data: not reported
Interventions	Type of interventions: Group 1: garlic cream 5% Group 2: vehicle Duration of intervention: both applied twice daily under occlusion with sterile gauze for 3 hours, for 20 days Duration of follow‐up: 60 days (after the 3 week treatment, participants were followed for another period of 40 days)
Outcomes	Healing rates: percentage of participants 'cured' one month (40 days) after treatment Time points reported: yes
Notes	Study funding sources: none reported Possible conflicts of interest: none declared We only have the abstract. The author (A Khamesipour) was contacted and kindly agreed to extract the data from the original paper written in Persian.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	List generated by a computer
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Low rates of dropouts (26/197; < 25%)
Selective reporting (reporting bias)	Unclear risk	All relevant outcomes reported
Other bias	Unclear risk	There was not enough information in the publication to assess if there were other biases present.