Jaffary 2010

Methods	Study design: randomised controlled trial Setting/location: Skin Disease and Leishmaniasis Research Center of Isfahan (SDLRC), Iran Study period: not described Sample size calculation: not described
Participants	Type of Leishmania: not described Inclusion criteria: not described Exclusion criteria: not described N randomised: 140 participants Withdrawals: 64 N assessed: 76 participants (47 with ILMA and topical Cassia fistula fruit gel and 29 participants in vehicle group) Age: not described Sex: not described Baseline data: not described
Interventions	Type of interventions: Group 1: Cassia fistula fruit gel + ILMA Group 2: vehicle gel + ILMA Duration of intervention: not described
Outcomes	Cure: complete cure, partial cure and treatment failure Adverse effects (itching and erythema) Time points reported: 12 weeks
Notes	Study funding sources: not reported Possible conflicts of interest: none declared We only have the abstract
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "140 patients with cutaneous leishmaniasis referring to Skin Diseases and Leishmaniasis Research Center of Isfahan (SDLRC) were randomly allocated in two groups" Comment: insufficient detail was reported about the method used to generate the allocation sequence.
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Comment: the vehicle came exactly in the same colour and shape as the drug and the application procedure was also the same. We think the outcome is unlikely to be influenced by lack of blinding of personnel.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	There is no information about withdrawals.
Selective reporting (reporting bias)	Low risk	Our primary outcomes (cured and adverse effects) were described in the Methods and reported in the text.
Other bias	High risk	Sample size calculation, inclusion criteria, reporting of Leishmania spp involved and baseline comparability was not correctly reported