Mashood 2001

Methods	Study design: randomised controlled trial Setting/location: skin department of PNS Shifa, a naval hospital in Karachi. Endemic areas of Balochistan province, Pakistan Study period: not described Sample size calculation: not described
Participants	Type of Leishmania: Leishmania spp not mentioned Inclusion criteria: never received any treatment for their skin disease Exclusion criteria: very young and very old people, those who had received some treatment for the disease, people suffering from diffuse CL or leishmaniasis recidivans, people with some known cardiac, renal or hepatic disease N randomised: 40. 20 in each group Withdrawals: 0 Participants assessed: 40 (100%). 20 in each group Age: range 20‐40 Sex: 100% male Baseline data. Nodular, ulcerative and crusted forms were the most common morphological patterns seen. Most lesions were on hands and feet. Group 1: MSL: 570.7 mm². MDLBT (range): 8.6 weeks (4‐20) Group 2: MSL: 960.3 mm². MDLBT: 12.6 weeks (8‐24)
Interventions	Type of interventions: Group 1: oral AL 20 mg/kg/d in 3‐4 divided doses tablet Group 2: IVSSG 20 mg/kg/d Duration of intervention: 15 days Duration of follow‐up: 3 months
Outcomes	Healing rates: percentage of participants 'cured' at the end of treatment Adverse effects Time points reported: at the end of treatment
Notes	Study funding sources: not reported Possible conflicts of interest: none declared
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: insufficient detail was reported about the method used to generate the allocation sequence.
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not described
Selective reporting (reporting bias)	Low risk	The study protocol is not available but it is probably that the published reports include all expected outcomes
Other bias	High risk	Sample size calculation and reporting of Leishmania spp involved was not correctly reported