Trial ID	Outcome	High risk of bias (category A)a	High risk of bias (category D)b	High risk of bias (category E)c	High risk of bias (category G)d
Da Qing 1997	Non‐fatal myocardial infarction	N/D	Yes (abstract mentions it was assessed)	N/D	N/D
	Non‐fatal stroke		Yes (abstract mentions it was assessed)
	Amputation of lower extremity		Yes (abstract mentions it was assessed)
DPP 2002	Serious adverse events		Yes
	Non‐fatal myocardial infarction		N/D	Yes
	Non‐fatal stroke			Yes
	Non‐serious adverse events		Yes	N/D
	Hypoglycaemia		Yes
DPS 2001	Cardiovascular mortality		Yes
	Non‐fatal myocardial infarction		Yes
	Non‐fatal stroke		Yes
EDIPS 2009	Health‐related quality of life		Yes
Hellgren 2016	N/D
HELP PD 2011	Serious adverse events	N/D	Yes	N/D
	Non‐serious adverse events		Yes
	Health‐related quality of life		Yes
	Time to progression to T2DM		Yes
IDPP 2006	Serious adverse events		Yes
	Non‐fatal myocardial infarction		Yes
	Non‐fatal stroke		Yes
	Non‐serious adverse events		N/D	Yes	N/D
JDPP 2013	Incidence of T2DM		Yes (long‐term (6 years) follow‐up of diabetes incidence)	N/D
	Serious adverse events	Yes	N/D
	Non‐serious adverse events	Yes
	Measures of blood glucose control		Yes
Kosaka 2005	All‐cause mortality	N/D		Yes
	Serious adverse events			Yes
	Cardiovascular mortality			Yes
	Non‐serious adverse events			Yes
	Measures of blood glucose control	N/D	Yes	N/D
Oldroyd 2005	N/D
PODOSA 2014	N/D
SLIM 2003	N/D
N/A: not applicable; N/D: none detected aClear that outcome was measured and analysed; trial report states that outcome was analysed but reports only that result was not significant (Classification 'A', table 2, Kirkham 2010). bClear that outcome was measured and analysed; trial report states that outcome was analysed but reports no results (Classification 'D', table 2, Kirkham 2010). cClear that outcome was measured but was not necessarily analysed; judgement says likely to have been analysed but not reported because of non‐significant results (Classification 'E', table 2, Kirkham 2010). dUnclear whether outcome was measured; not mentioned, but clinical judgement says likely to have been measured and analysed but not reported on the basis of non‐significant results (Classification 'G', table 2, Kirkham 2010).