Trial ID	Intervention(s) and comparator(s)	Participants included in analysis (N)	Participants discontinuing trial due to an adverse event (N)	Participants discontinuing trial due to an adverse event (%)	Participants with at least one hospitalisation (N)	Participants with at least one hospitalisation (%)	Participants with at least one outpatient treatment (N)	Participants with at least one outpatient treatment (%)
Da Qing 1997	I1: diet	130	0	0	‐	‐	‐	‐
	I2: physical activity	131	0	0	‐	‐	‐	‐
	I3: diet plus physical activity	126	0	0	‐	‐	‐	‐
	C: standard treatment	133	0	0	‐	‐	‐	‐
DPP 2002	I: diet plus physical activity	1079	‐	‐	‐	‐	‐	‐
	C: placebo + standard treatment	1082	‐	‐	‐	‐	‐	‐
DPS 2001	I: diet plus physical activity	265	‐	‐	‐	‐	‐	‐
	C: standard treatment	257	‐	‐	‐	‐	‐	‐
EDIPS 2009	I: diet plus physical activity	51	1	2.0	‐	‐	‐	‐
	C: standard treatment	51	0	0	‐	‐	‐	‐
Hellgren 2016	I: physical activity	84	1	1.1	‐	‐	‐	‐
	C: standard treatment	39	1	2.5	‐	‐	‐	‐
HELP PD 2011	I: diet plus physical activity	151	‐	‐	‐	‐	‐	‐
	C: standard treatment	150	‐	‐	‐	‐	‐	‐
IDPP 2006	I: diet plus physical activity	120	0	0	‐	‐	‐	‐
	C: standard treatment	133	0	0	‐	‐	‐	‐
JDPP 2013	I: diet plus physical activity	103	2	0	‐	‐	‐	‐
	C: standard treatment	110	2	0	‐	‐	‐	‐
Kosaka 2005	I: diet plus physical activity	102	‐	‐	‐	‐	‐	‐
	C: standard treatment	356	‐	‐	‐	‐	‐	‐
Oldroyd 2005	I: diet plus physical activity	37 at 6 months 32 at 12 months 30 at 24 months	‐	‐	‐	‐	‐	‐
	C: no intervention	32 at 6 months 30 at 12 months 24 at 24 months	‐	‐	‐	‐	‐	‐
PODOSA 2014	I: diet plus physical activity	85	‐	‐	‐	‐	‐	‐
	C: standard treatment	86	‐	‐	‐	‐	‐	‐
SLIM 2003	I: diet plus physical activity	74 at baseline 52 at 3 years 51 at 4 years 34 at 5 years 35 (one that was missing at five years attended 6‐year follow‐up) at 6 years	‐	‐	‐	‐	‐	‐
	C: standard treatment	73 at baseline 54 at 3 years 43 at 4 years 29 at 5 years 35 (six that were missing at five years attended 6‐year follow‐up) at 6 years	‐	‐	‐	‐	‐	‐
‐ denotes not reported C: comparator; I: intervention