Table 4.
Class‐level interventions | SUCRA PASI 90 | Rank PASI 90 | SUCRA SAE | Rank SAE | SUCRA PASI 75 | Rank PASI 75 | SUCRA AE | Rank AE | SUCRA PGA | Rank PGA | SUCRA QoL | Rank QoL |
Anti‐IL12/23 | 85.7 | 2 | 53.9 | 3 | 85.0 | 2 | 57.0 | 3 | 83.8 | 2 | 75.7 | 3 |
Anti‐IL17 | 100.0 | 1 | 21.0 | 8 | 99.6 | 1 | 14.1 | 6 | 99.9 | 1 | 95.4 | 1 |
Anti‐IL23 | 71.3 | 3 | 39.6 | 5 | 72.2 | 3 | 78.7 | 2 | 73.1 | 3 | 83.4 | 2 |
Anti‐TNF alpha | 56.4 | 4 | 39.2 | 6 | 57.4 | 4 | 47.5 | 5 | 57.5 | 4 | 58.4 | 4 |
Other biologics | 26.3 | 6 | 68.2 | 2 | 17.0 | 7 | _ | _ | 16.6 | 7 | 15.5 | 7 |
Small molecules | 41.5 | 5 | 45.4 | 4 | 42.7 | 5 | 7.9 | 7 | 42.0 | 5 | 40.4 | 5 |
Conventional systemic treatments |
18.7 | 7 | 94.8 | 1 | 26.0 | 6 | 50.8 | 4 | 27.1 | 6 | 30.8 | 6 |
Placebo | 0 | 8 | 38.0 | 7 | 0 | 8 | 94.0 | 1 | 0 | 8 | 0.4 | 8 |
AE: adverse events; FAEs: fumaric acid esters; PGA: Physician Global Assessment; QoL: Specific quality of life scale; SAE: serious adverse events