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. 2015 Jun 30;2015(6):CD010037. doi: 10.1002/14651858.CD010037.pub2
Methods Randomised double‐blind clinical trial. . Women were divided into a control and an experimental group in a
The trial was conducted in the United States of America.
Participants 81 normotensive and 34 medicated hypertensive women.
Age: between 35 and 65 years.
Interventions Intervention group: 3 daily tablets of a calcium carbonate supplement containing 500 mg calcium‐tablet .
Control group: placebo tablets.
Trial duration: 4‐year.
Outcomes Bone mineral content and blood pressure
Notes Most of the women were using thiazides
"Dietary calcium of all women was determined using a precoded food record form, which had been tested for validity against weighed food intakes."
This study was supported by Wisconsin Milk Marketing Board, Inc, Marion Laboratories, Kansas City, MO
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding of participants and personnel (performance bias) All outcomes Unclear risk "The original group of women, including the hypertensives, was divided into a control and an experimental group in a double‐blind design." However methods were not described.
Blinding of outcome assessment (detection bias) All outcomes Unclear risk "Blood pressure was measured from the right arm of seated participants using a standard mercury sphygmomanometer." Not reported if outcome assessors were blinded to the intervention.
Incomplete outcome data (attrition bias) All outcomes High risk 44 participants were randomised to the intervention and 41 were analysed. 51 participants were randomized to placebo and 40 were analysed.
Selective reporting (reporting bias) Low risk All primary outcomes were reported
Other bias Low risk Baseline characteristics were similar between the groups.