Author (Year)
Journal
Title
Risk of Bias Assessment (with quotes and or statement)		High Risk of Bias	Low Risk of Bias	Unclear Risk of Bias
Random sequence generation (selection bias)
State here the method used to generate the sequence
Allocation concealment (selection bias)
State here the method used to conceal allocation
Blinding of participants and personnel (performance bias)
Persons responsible for participants care
Participants
Blinding of outcome assessment (detection bias)
Outcome assessor
Incomplete outcome data (attrition bias)
Adequate, if drop‐out rate ≤ 15% and balanced between arms and reasons for missing values reported, and unrelated to the analysed outcome (data analysis described and imputation methods correct).
Selective reporting (reporting bias)
Adequate, if a prospectively registered study protocol is available and all predefined primary and secondary outcomes are also reported in the published study.
Other bias
Other sources of bias (e.g. imbalance in baseline characteristics between study's arms)