Imamura 1989.

Methods	Country where data collected: Japan Parallel group RCT Unit of randomisation: participant Unit of analysis: participant Duration: 8 weeks (8 weeks follow‐up duration)
Participants	Inclusion criteria: participants with pressure ulcers stages 1‐4 treated in hospital Exclusion criteria: not reported Participants: N = 141 (randomised); 139 analysed of whom 109 had stage 2 or above pressure ulcers Mean age: Not reported Number of males: 37/71 vs 30/68 Ulcer stage: stage 1 16 vs 14; stage 2 or 3 31 vs 26; stage 4 24 vs 28 Ulcer location: sacrum 51 vs 45; ischium 6 vs 6; back 6 vs 4; greater trochanter 4 vs 4; ilium 1 vs 6; other 3 vs 4. Ulcer size (cm²): 25.48 (SE 4.34) vs 29.29 (SE 4.65)
Interventions	Intervention arm 1: KT‐136 (sugar (70g/100g) and povidone iodine (3g/100g)) ointment applied directly on to the wound or to the gauze sheet applied to the wound. Application once or twice a day. Intervention arm 2: lysozyme ointment (5g/100g) applied directly on to the wound or to the gauze sheet applied to the wound. Application once or twice a day. Cointerventions: none reported
Outcomes	Primary outcome: proportion of wounds completely healed Primary outcome: adverse events and serious adverse events Secondary outcome: wound area reduction Secondary outcome: infection
Notes	Trial published entirely in Japanese; assessment for inclusion, data extraction and risk of bias assessment all conducted by one review author Funding: NR
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random number table used
Allocation concealment (selection bias)	Low risk	Central telephone allocation
Blinding of outcome assessment (detection bias) All outcomes	High risk	No blinding was used
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No reasons were provided for missing data
Selective reporting (reporting bias)	Unclear risk	This was unclear due to poor reporting
Other bias	Unclear risk	Multiple sources of uncertainty