Toba 1997.

Methods	Country where data collected: Japan Parallel group RCT Unit of randomisation: participant Unit of analysis: participant Duration: 14 weeks (duration), 2 years (follow‐up)
Participants	Inclusion criteria: detected MRSA from ulcers in previous month Excusion criteria: not reported N: 19 participants N males: 0/19 Mean age (years): 83.5 ± 3.0 years old Participants were hospital inpatients with cerebrovascular disorder, without diabetes, malignant tumours and liver dysfunctions
Interventions	Intervention arm 1: GVcAMP (base: polyethylene glycol (SOLBASE), 0.1% Gentian Violet (Piokutanin): Dibutyryl cAMP (Actsin) = 1:1) Intervention arm 2: IS (Iodine Sugar(U‐PASTA))
Outcomes	Primary outcome: adverse events Secondary outcome: wound area reduction Secondary outcome: infection (microbiological data only)
Notes	Trial published in Japanese; data extraction and risk of bias assessment conducted by single translator. Assessed as meeting inclusion criteria for pressure ulcers (and stages) by translator. Funding: NR
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised by using a table of random numbers
Allocation concealment (selection bias)	Unclear risk	Using a table of random numbers which was unclear whether open or not
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	There were no dropouts
Selective reporting (reporting bias)	Unclear risk	The protocol is not available, insufficient information to permit judgement
Other bias	Unclear risk	Some sources of uncertainty