Analysis 15.1.

Comparison 15 Lixisenatide versus placebo, Outcome 1 HbA1c (%).

HbA1c (%)

Study	LIXI 5 μg QD	LIXI 10 μg QD	LIXI 20 μg QD	LIXI 30 μg QD	LIXI 5 μg BID	LIXI 10 μg BID	LIXI 20 μg BID	LIXI 30 μg BID	Placebo	p values
Lixi ‐ Ratner 2010	‐0.47	‐0.5	‐0.69	‐0.76	‐0.65	‐0.78	‐0.75	‐0.87	‐0.18	change from baseline to end: LIXI: P < 0.05 for all doses