Adverse events

Study	Description	10 mg weekly	20 mg weekly	20 mg every 2 weeks	Placebo
T ‐ Nauck 2009	withdrawal due to adverse event	n = 2	n = 3	n = 1	n = 0
T ‐ Nauck 2009	adverse events similar across groups for: headache no clinically relevant abnormalities in ECG, vital signs, laboratory parameters
T ‐ Nauck 2009	nausea	n = 12 (24%)	n = 26 (52%)	n = 20 (41%)	n = 3 (6%)
T ‐ Nauck 2009	vomiting	n = 2 (4%)	n = 11 (22%)	n = 12 (24%)	n = 2 (4%)
T ‐ Nauck 2009	diarrhoea	n = 5 (10%)	n = 5 (10%)	n = 9 (18%)	n = 4 (8%)
T ‐ Nauck 2009	serious adverse events: 6 patients, 2 of which in placebo group considered to be unrelated to study treatment
T ‐ Nauck 2009	mild and moderate injection site reactions which did not result in treatment discontinuation