Interventions to improve psychosocial well‐being in female BRCA‐mutation carriers following risk‐reducing surgery
Patient or population: adult women, 18 years or older, who have tested positive for a pathogenic mutation in BRCA1 orBRCA2, or both and had risk‐reducing surgery Settings: outpatient Intervention: psychosocial interventions designed to improve quality of life (QoL) Comparison: no intervention
Outcomes	Illustrative comparative risks*		Relative effect (95% CI)	Number of participants (studies)	Quality of the evidence (GRADE)	Comment
	Assumed risk	Corresponding risk
Improved QoL
Psychological distress
Sexual functioning
Body image
Psychosocial well‐being
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). Abbreviations: CI: confidence interval; QoL: quality of life.
GRADE Working Group grades of evidence High quality: further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: we are very uncertain about the estimate.