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. 2019 Apr 2;129(5):1910–1925. doi: 10.1172/JCI121668

Figure 3. Increased IL7R mRNA and IL-7Rα protein expression in UC and CD colon mucosa.

Figure 3

(A and B) Relative IL7 and IL7R expression, as measured by RT-PCR, of colon biopsies from inflamed and healthy areas of UC (n = 21) (A) and CD (n = 24) (B) patients compared with non-IBD control patients (n = 20). Each symbol represents 1 patient, bars represent means, and error bars show SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 between indicated groups. (C) Representative IL-7Rα immunohistochemical staining of colonic biopsy specimens from non-IBD control (infectious acute colitis) and inactive and active UC or CD (scale bars: top and middle, 100 μm; bottom, higher-magnification images of the panels above, 50 μm).