Table 1. Clinical Trials Currently Registered in the NLM's Clinical Trials Database ( www.clinicaltrials.gov ) .

Study ID	Study title	Intervention	Sponsor	Status
NCT01444846	Otoprotection with SPI-1005 for prevention of temporary auditory threshold shift	Ebselen	SPI-1005, Sound Pharmaceuticals Inc	Completed, has results
NCT00808470	Micronutrients to prevent noise-induced hearing loss	β-Carotene, vitamins C and E, magnesium	University of Michigan	Completed, has results
NCT00552786	Antioxidation medication for noise-induced hearing loss	N-acetylcysteine (NAC)	National Taiwan University Hospital	Completed, has results
NCT02259595	Study to determine the safety, tolerability, and pharmacokinetic profile of HPN-07 and HPN-07 plus NAC	HPN-07 and NAC	Otologic Pharmaceutics, Inc.	Completed
NCT02257983	Protective effects of EPI-743 on noise-induced hearing loss	Vincerinone EPI-743	Edison Pharmaceuticals, Inc.	Completed
NCT00802425	Efficacy of AM-111 in patients with acute sensorineural hearing loss	AM-111	Auris Medical AG	Completed
NCT02903355	Phase 3 clinical trial: D-methionine to reduce noise-induced hearing loss (NIHL)	D-methionine	Southern Illinois University	Terminated
NCT02049073	Prevention of noise-induced hearing loss	Zonisamide and methylprednisolone	Washington University School of Medicine	Withdrawn
NCT01727492	Prevention of noise-induced damage by use of antioxidants	NAC and magnesium	University Hospital, Antwerp	Unknown
NCT02779192	A phase 2b study of SPI-1005 to prevent acute noise induced hearing loss (PANIHL)	Ebselen	SPI-1005, Sound Pharmaceuticals, Inc	Not yet recruiting

Note: Clinical Trials Currently Registered in the NLM's Clinical Trials Database ( www.clinicaltrials.gov ) as of October 5, 2018, as identified using search terms “noise induced hearing less” and “temporary threshold shift”

Abbreviation: NLM, National Library of Medicine.