Table 4.
Unadjusted 1-Year Outcomes in Successfully Recanalized CTO Lesions
| Intraplaque Tracking (n = 73) | Subintimal Tracking (n = 84) | HR/OR;* 95% CI | P Value log rank | |
|---|---|---|---|---|
| 1-Year outcomes | ||||
| Target Vessel Failure† | 5 (6.9) | 15 (17.9) | 2.74 (1.00–7.54) | 0.04 |
| Major Adverse Cardiovascular Events | 7 (9.6) | 17 (20.3) | 2.24 (0.93–5.41) | 0.06 |
| All-Cause Death | 3 (4.1) | 3 (3.6) | 0.86 (0.17– 4.24) | 0.85 |
| Cardiovascular Death | 2 (2.8) | 2 (2.4) | 0.86 (0.12–6.10) | 0.88 |
| Target Vessel MI | 2 (1.9) | 8 (9.6) | 3.52 (0.75–16.60) | 0.08 |
| Peri-Procedural MI | 2 (2.7) | 6 (7.14) | 2.73 (0.53–13.97)* | 0.29 |
| Definite/ Probable Stent Thrombosis | 1 (1.4%) | 0 (0.0) | 0.29 (0.012–7.13)* | 0.47 |
| Target Vessel Revascularization | 2 (2.8) | 7 (8.5) | 3.12 (0.64–15.03) | 0.13 |
| Coronary Artery Bypass Grafting | 0 (0.0) | 1 (1.19) | 2.64 (0.11–65.8)* | 1.0 |
| Cardiovascular Rehospitalization | 9 (12.7) | 8 (9.7) | 0.71 (0.28–1.85) | 0.51 |
| Change In Ejection Fraction | +2.0% ± 11 | +3.7% ± 12.2 | 0.59 | |
| Periprocedural Clinical Events | ||||
| Clinically Significant Perforation‡ | 1 (1.4) | 7 (8.3) | 6.54 (0.79–54.52)* | 0.07 |
| Tamponade | 1 (1.4) | 2 (2.4) | 1.76 (0.16–19.77)* | 1.0 |
| Wire Perforation | 3 (4.1) | 13 (15.5) | 4.27 (1.17 −15.65)* | 0.03 |
| Emergent Surgery/CABG | 1 (1.37) | 1 (1.19) | 0.88 (0.05 −14.12)* | 1.0 |
| Branch Occlusion (diameter >1.5 mm) | 12 (16.4) | 41 (48.8) | 4.85 (2.28 −10.29)* | <0.0001 |
| Acute Renal Failure | 1 (1.0) | 1 (0.9) | 0.87 (0.05–14.10)* | 1.0 |
| Length of Stay§ | 1.9 ± 3.8 | 2.4 ± 3.8 | 0.04 | |
| Active Medication Use At 1-year | ||||
| Aspirin | 68/71 (95.8) | 74/76 (97.3) | 1.63 (0.26–10.07)* | 0.50 |
| Dual Antiplatelet Therapy | 64/70 (91.4) | 71/76 (93.4) | 1.33 (0.38–4.57)* | 0.65 |
| Clopidogrel | 47/70 (67.14) | 52 /76 (68.4) | ||
| Ticagrelor | 7/70 (10.0) | 8/76 (10.5) | ||
| Prasugrel | 10/70 (14.3) | 11/76 (14.5) | ||
| Coumadin | 5/68 (7.4) | 5/71 (7.0) | 0.95 (0.26–3.46)* | 1.0 |
PMI = peri-procedural myocardial infarction, MI – myocardial infarction, CABG = Coronary Artery Bypass Grafting
*
represent odds ratio
†
composite of cardiovascular death, target vessel MI, and Target vessel revascularization‡composite of all-cause death, myocardial infarction and unplanned revascularization
‡
Perforation requiring treatment with prolonged balloon inflation, pericardiocentesis, coils, beads thrombin, or surgery.
§
From date of index procedure to discharge