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. Author manuscript; available in PMC: 2019 Jul 10.
Published in final edited form as: Oncogene. 2019 Jan 10;38(17):3274–3287. doi: 10.1038/s41388-018-0633-1

Figure 6.

Figure 6.

p73 is necessary for differentiation-dependent HPV genome amplification. A). Western blot analysis of p73 and GAPDH proteins in monolayer CIN612 cells infected with multiple shRNA lentiviruses targeting p73. B). Western blot analysis of p73 and GAPDH proteins in CIN612 cells with TopBP1 knockdown upon differentiation in high-calcium media for 72 hours. Southern blot analysis of HPV31 episomes in CIN612 cells with TopBP1 knockdown following differentiation in high calcium media for 72 hrs. All results are representative of observations from 2 or more independent experiments.