Table 3.

Multiple regression analyses of neurocognitive and quality of life outcomes that differed between survivors with versus without growth hormone deficiency.

		Vocabulary		Visual Speed		Flexibility		Fluency		Task Efficiency		Emotional Regulation
		Est.	P-value	Est.	P-value	Est.	P-value	Est.	P-value	Est.	P-value	Est.	P-value
GHD	Yes v. No	−0.08	0.41	−0.07	0.45	−0.21	0.21	−0.19	0.046	−0.16	0.20	−0.19	0.06
Hypothyroidism	Yes v. No	−0.06	0.67	−0.16	0.17	−0.28	0.23	−0.25	0.051	−0.37	0.03	0.01	0.98
Hypogonadism	Yes v. No	0.11	0.37	0.06	0.58	0.06	0.76	0.03	0.77	0.14	0.37	0.22	0.07
Sex	Female	−0.23	0.02	0.10	0.28	−0.02	0.91	0.06	0.51	−0.32	0.01	−0.44	<0.001
Age at diagnosis	Per year	0.05	<0.001	0.03	0.003	0.09	<0.001	0.04	0.002	0.02	0.27	0.01	0.37
Time since diagnosis	Per 10 years	0.09	0.38	0.21	0.02	0.48	0.005	0.07	0.49	0.21	0.12	0.10	0.34
CRT dose	Per 10 Gy	−0.37	0.002	−0.58	<0.001	−1.12	<0.001	−0.28	0.01	−0.26	0.11	−0.09	0.46
IT Methotrexate	Per 100 ml	−0.02	0.68	−0.03	0.40	0.08	0.32	0.01	0.83	0.04	0.46	0.04	0.43
HDIV Methotrexate	Yes v. No	0.31	0.04	0.35	0.009	0.14	0.58	0.37	0.009	0.53	0.005	0.27	0.08
		Physical Function		Bodily Pain		General Health		Vitality		Social Function		Mental Health
		Est.	P-value	Est.	P-value	Est.	P-value	Est.	P-value	Est.	P-value	Est.	P-value
GHD	Yes v. No	−0.14	0.12	−0.18	0.06	−0.26	0.01	−0.24	0.01	−0.18	0.06	−0.26	0.01
Hypothyroidism	Yes v. No	−0.20	0.09	−0.26	0.04	−0.51	<0.001	−0.43	0.001	−0.26	0.04	−0.15	0.29
Hypogonadism	Yes v. No	−0.13	0.20	0.07	0.52	0.02	0.86	0.01	0.93	−0.01	0.98	−0.02	0.89
Sex	Female	−0.26	0.004	−0.18	0.06	−0.16	0.11	−0.31	0.001	−0.11	0.25	−0.18	0.08
Age at diagnosis	Per year	−0.01	0.24	−0.03	0.03	−0.03	0.01	−0.03	0.005	−0.02	0.12	−0.03	0.02
Time since diagnosis	Per 10 years	0.08	0.37	0.06	0.55	0.18	0.08	0.12	0.21	0.13	0.17	0.15	0.14
CRT dose	Per 10 Gy	−0.46	<0.001	−0.21	0.046	−0.08	0.52	−0.12	0.29	−0.23	0.03	−0.06	0.58
IT Methotrexate	Per 100 ml	0.06	0.15	0.03	0.52	0.01	0.94	0.01	0.91	0.02	0.65	−0.01	0.91
HDIV Methotrexate	Yes v. No	0.08	0.56	0.05	0.75	0.49	0.001	0.20	0.15	0.26	0.06	0.24	0.11

Abbreviations: GHD = growth hormone deficiency, CRT = cranial radiation therapy, IT = intrathecal (either single methotrexate or methotrexate combined with cytarabine and hydrocortisone), HDIV = high-dose intravenous.